Protein phosphatase 1 regulatory subunit 29

UniProt data

UniProt name: PPR29_HUMAN (Q5R3F8)

Gene name: ELFN2; Synonyms=KIAA1904, LRRC62, PPP1R29

Organism: Homo sapiens (Human).

Function: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 398-418, 21 AA, Helical. {ECO:0000255}.

Sequence: 820 AA

10 20 30 40 50 60 MLRLGLCAAA LLCVCRPGAV RADCWLIEGD KGYVWLAICS QNQPPYETIP QHINSTVHDL 70 80 90 100 110 120 RLNENKLKAV LYSSLNRFGN LTDLNLTKNE ISYIEDGAFL GQSSLQVLQL GYNKLSNLTE 130 140 150 160 170 180 GMLRGMSRLQ FLFVQHNLIE VVTPTAFSEC PSLISIDLSS NRLSRLDGAT FASLASLMVC 190 200 210 220 230 240 ELAGNPFNCE CDLFGFLAWL VVFNNVTKNY DRLQCESPRE FAGYPLLVPR PYHSLNAITV 250 260 270 280 290 300 LQAKCRNGSL PARPVSHPTP YSTDAQREPD ENSGFNPDEI LSVEPPASST TDASAGPAIK 310 320 330 340 350 360 LHHVTFTSAT LVVIIPHPYS KMYILVQYNN SYFSDVMTLK NKKEIVTLDK LRAHTEYTFC 370 380 390 400 410 420 VTSLRNSRRF NHTCLTFTTR DPVPGDLAPS TSTTTHYIMT ILGCLFGMVI VLGAVYYCLR 430 440 450 460 470 480 KRRMQEEKQK SVNVKKTILE MRYGADVDAG SIVHAAQKLG EPPVLPVSRM ASIPSMIGEK 490 500 510 520 530 540 LPTAKGLEAG LDTPKVATKG NYIEVRTGAG GDGLARPEDD LPDLENGQGS AAEISTIAKE 550 560 570 580 590 600 VDKVNQIINN CIDALKLDSA SFLGGGSSSG DPELAFECQS LPAAAAASSA TGPGALERPS 610 620 630 640 650 660 FLSPPYKESS HHPLQRQLSA DAAVTRKTCS VSSSGSIKSA KVFSLDVPDH PAATGLAKGD 670 680 690 700 710 720 SKYIEKGSPL NSPLDRLPLV PAGSGGGSGG GGGIHHLEVK PAYHCSEHRH SFPALYYEEG 730 740 750 760 770 780 ADSLSQRVSF LKPLTRSKRD STYSQLSPRH YYSGYSSSPE YSSESTHKIW ERFRPYKKHH 790 800 810 REEVYMAAGH ALRKKVQFAK DEDLHDILDY WKGVSAQQKL

CATM prediction

The sequence of PPR29_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       400       410       42
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 THYIMTILGCLFGMVIVLGAVYYCLRK 6.5 -47.8° 0.7 54.4 -34.9
Model 2 THYIMTILGCLFGMVIVLGAVYYCLRK 7.2 -45.9° 4.6 38.3 -14.0
Model 3 THYIMTILGCLFGMVIVLGAVYYCLRK 7.4 -45.1° 4.0 38.9 -8.4
Model 4 THYIMTILGCLFGMVIVLGAVYYCLRK 6.9 -55.2° 1.5 45.1 -8.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 400, THR, HA A, 399, MET, O 2.77Å
B, 403, GLY, HA1 A, 400, THR, O 2.45Å
B, 404, CYS, HA A, 403, GLY, O 2.80Å
A, 400, THR, HA B, 399, MET, O 2.77Å
A, 403, GLY, HA1 B, 400, THR, O 2.45Å
A, 404, CYS, HA B, 403, GLY, O 2.80Å