C-type lectin domain family 12 member A

UniProt data

UniProt name: CL12A_HUMAN (Q5QGZ9)

Gene name: CLEC12A; Synonyms=CLL1, DCAL2, MICL

Organism: Homo sapiens (Human).

Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. Note=Ligand binding leads to internalization.

Transmembrane domains:

  1. 44-64, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 265 AA

10 20 30 40 50 60 MSEEVTYADL QFQNSSEMEK IPEIGKFGEK APPAPSHVWR PAALFLTLLC LLLLIGLGVL 70 80 90 100 110 120 ASMFHVTLKI EMKKMNKLQN ISEELQRNIS LQLMSNMNIS NKIRNLSTTL QTIATKLCRE 130 140 150 160 170 180 LYSKEQEHKC KPCPRRWIWH KDSCYFLSDD VQTWQESKMA CAAQNASLLK INNKNALEFI 190 200 210 220 230 240 KSQSRSYDYW LGLSPEEDST RGMRVDNIIN SSAWVIRNAP DLNNMYCGYI NRLYVQYYHC 250 260 TYKKRMICEK MANPVQLGST YFREA

CATM prediction

The sequence of CL12A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           50        60      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 AAALFLTLLCLLLLIGLGVLASMFHVT 7.1 -55.0° 0.9 50.1 -0.9
Prolines* PAALFLTLLCLLLLIGLGVLASMFHVT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 58, GLY, HA1 A, 55, ILE, O 3.33Å
B, 59, VAL, HA A, 58, GLY, O 3.43Å
B, 62, SER, HG1 A, 59, VAL, O 2.66Å
A, 58, GLY, HA1 B, 55, ILE, O 3.33Å
A, 59, VAL, HA B, 58, GLY, O 3.43Å
A, 62, SER, HG1 B, 59, VAL, O 2.66Å