Ephrin type-A receptor 10

UniProt data

UniProt name: EPHAA_HUMAN (Q5JZY3)

Gene name: EPHA10

Organism: Homo sapiens (Human).

Function: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. {ECO:0000269|PubMed:15777695}.

Subcellular location: Isoform 2: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 566-586, 21 AA, Helical. {ECO:0000255}.

Sequence: 1008 AA

10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 300 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 310 320 330 340 350 360 PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 370 380 390 400 410 420 PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 430 440 450 460 470 480 YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEDEI RRDRVEPQSV SLSWREPIPA 490 500 510 520 530 540 GAPGANDTEY EIRYYEKGQS EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 550 560 570 580 590 600 QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 610 620 630 640 650 660 DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 670 680 690 700 710 720 CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 730 740 750 760 770 780 IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 790 800 810 820 830 840 DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 850 860 870 880 890 900 AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 910 920 930 940 950 960 SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY KDSFAAAGYG 970 980 990 1000 SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ LQGQGVQV

CATM prediction

The sequence of EPHAA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         570       580       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SAAIVVTVVTISALLVLGSVMSVLAIW 7.2 -51.7° 0.6 48.0 -19.1
Prolines* SPAIVVTVVTISALLVLGSVMSVLAIW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 580, GLY, HA1 A, 577, LEU, O 3.28Å
B, 581, SER, HA A, 580, GLY, O 3.37Å
B, 584, SER, HG1 A, 581, SER, O 2.45Å
A, 580, GLY, HA1 B, 577, LEU, O 3.28Å
A, 581, SER, HA B, 580, GLY, O 3.37Å
A, 584, SER, HG1 B, 581, SER, O 2.45Å