RRP12-like protein

UniProt data

UniProt name: RRP12_HUMAN (Q5JTH9)

Gene name: RRP12; Synonyms=KIAA0690

Organism: Homo sapiens (Human).

Function:

Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 903-923, 21 AA, Helical. {ECO:0000255}.

Sequence: 1297 AA

10 20 30 40 50 60 MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD LTVDAVKLHN 70 80 90 100 110 120 ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA 130 140 150 160 170 180 HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS 190 200 210 220 230 240 PVLIKKFSDT SKAFMDIMSA QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG 250 260 270 280 290 300 LLSFTVHPKP KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE 310 320 330 340 350 360 ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH SLFHARPGLS 370 380 390 400 410 420 TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN LVRLQWDLGL GHLPRFFGTA 430 440 450 460 470 480 VTCLLSPHSQ VLTAATQSLK EILKECVAPH MADIGSVTSS ASGPAQSVAK MFRAVEEGLT 490 500 510 520 530 540 YKFHAAWSSV LQLLCVFFEA CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT 550 560 570 580 590 600 SMGPEVVLQA VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA 610 620 630 640 650 660 MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA ISERPDLRVT 670 680 690 700 710 720 VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP VAAGDTPAPR RAVLETIRTY 730 740 750 760 770 780 LTITDTQLVN SLLEKASEKV LDPASSDFTR LSVLDLVVAL APCADEAAIS KLYSTIRPYL 790 800 810 820 830 840 ESKAHGVQKK AYRVLEEVCA SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL 850 860 870 880 890 900 LHIVRKLSAE HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ 910 920 930 940 950 960 CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL LASRTRDVVK 970 980 990 1000 1010 1020 SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF RMKLRNLFTK FIRKFGFELV 1030 1040 1050 1060 1070 1080 KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ AAVEEEEEEE EEEEPAQGKG DSIEEILADS 1090 1100 1110 1120 1130 1140 EDEEDNEEEE RSRGKEQRKL ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR 1150 1160 1170 1180 1190 1200 KKDHGFKVSA DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE 1210 1220 1230 1240 1250 1260 AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP YAYIPLNRSK 1270 1280 1290 LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP

CATM prediction

The sequence of RRP12_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  900       910       920    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 QCYLVLIYAGLVGAVTMVSCSILALTH 6.7 -49.9° 2.8 47.0 -23.4
Model 2 QCYLVLIYAGLVGAVTMVSCSILALTH 7.3 -50.8° 2.4 44.7 -18.1
Prolines* QCYLVLIYPGLVGAVTMVSCSILALTH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 909, GLY, HA2 A, 908, ALA, O 2.70Å
B, 912, GLY, HA1 A, 909, GLY, O 2.65Å
A, 909, GLY, HA2 B, 908, ALA, O 2.70Å
A, 912, GLY, HA1 B, 909, GLY, O 2.65Å