Protein crumbs homolog 2

UniProt data

UniProt name: CRUM2_HUMAN (Q5IJ48)

Gene name: CRB2

Organism: Homo sapiens (Human).

Function: May play a role in polarized cells morphogenesis.

Subcellular location: Isoform 2: Secreted {ECO:0000255}.

Transmembrane domains:

  1. 1225-1245, 21 AA, Helical. {ECO:0000255}.

Sequence: 1285 AA

10 20 30 40 50 60 MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG TECQATESGG 70 80 90 100 110 120 YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF QGPRCELDID ECASRPCHHG 130 140 150 160 170 180 ATCRNLADRY ECHCPLGYAG VTCEMEVDEC ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR 190 200 210 220 230 240 CQLDLDECQS QPCAHGGTCH DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE 250 260 270 280 290 300 GLGSFRCLCW PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH 310 320 330 340 350 360 AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY AGPTCEEDVD 370 380 390 400 410 420 ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC QGHTCPLAAT CIPIFESGVH 430 440 450 460 470 480 SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ ASVPAGGPLG LALRFRTTLP AGTLATRNDT 490 500 510 520 530 540 KESLELALVA ATLQATLWSY STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC 550 560 570 580 590 600 PARLCVASGP VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL 610 620 630 640 650 660 LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG LGGAPSSASF 670 680 690 700 710 720 LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL SEGRIRAEVP GSPAVVLPGR 730 740 750 760 770 780 WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR LLAADSQPWG GPFRGCLQDL RLDGCHLPFF 790 800 810 820 830 840 PLPLDNSSQP SELGGRQSWN LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP 850 860 870 880 890 900 TCAQQLWCPG QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF 910 920 930 940 950 960 RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR VADGAWHRVR 970 980 990 1000 1010 1020 LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG AVRILLAENF TGCLGRVALG 1030 1040 1050 1060 1070 1080 GLPLPLARPR PGAAPGAREH FASWPGTPAP ILGCRGAPVC APSPCLHDGA CRDLFDAFAC 1090 1100 1110 1120 1130 1140 ACGPGWEGPR CEAHVDPCHS APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL 1150 1160 1170 1180 1190 1200 NVTCLDGSPC EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN 1210 1220 1230 1240 1250 1260 ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK RRQSEGTYSP 1270 1280 SQQEVAGARL EMDSVLKVPP EERLI

CATM prediction

The sequence of CRUM2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          1230      1240     
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 LLEVAVAAACACLLLLLLGLLSGILAA 7.0 -47.8° 0.8 53.9 -31.4
Prolines* LLEVAVPAACACLLLLLLGLLSGILAA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1240, GLY, HA1 A, 1237, LEU, O 3.20Å
B, 1241, LEU, HA A, 1240, GLY, O 3.16Å
A, 1240, GLY, HA1 B, 1237, LEU, O 3.20Å
A, 1241, LEU, HA B, 1240, GLY, O 3.16Å