UniProt data
UniProt name: IGS11_HUMAN (Q5DX21)
Gene name: IGSF11; Synonyms=BTIGSF, CXADRL1, VSIG3
Organism: Homo sapiens (Human).
Function: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. {ECO:0000269|PubMed:15795899, ECO:0000269|PubMed:16108831}.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Transmembrane domains:
- 242-262, 21 AA, Helical. {ECO:0000255}.
Sequence: 431 AA
CATM prediction
The sequence of IGS11_HUMAN returned 6 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 240 250 260 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | NIGLIAGAIGTGAVIIIFCIALILGAF | 7.1 | -45.8° | 4.7 | 37.8 | -29.2 |
| Model 2 | NIGLIAGAIGTGAVIIIFCIALILGAF | 7.3 | -53.6° | 3.6 | 49.2 | -23.6 |
| Model 3 | NIGLIAGAIGTGAVIIIFCIALILGAF | 7.3 | -41.2° | 3.4 | 38.0 | -19.1 |
| Model 4 | NIGLIAGAIGTGAVIIIFCIALILGAF | 6.8 | -49.0° | 5.4 | 48.9 | -16.3 |
| Model 5 | NIGLIAGAIGTGAVIIIFCIALILGAF | 6.6 | +35.0° | 4.5 | 74.0 | -16.3 |
| Model 6 | NIGLIAGAIGTGAVIIIFCIALILGAF | 6.8 | +52.0° | 1.8 | 1.0 | -10.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 245, GLY, HA2 | A, 244, ALA, O | 3.01Å |
| B, 248, GLY, HA1 | A, 245, GLY, O | 3.31Å |
| A, 245, GLY, HA2 | B, 244, ALA, O | 3.01Å |
| A, 248, GLY, HA1 | B, 245, GLY, O | 3.31Å |
