Seizure protein 6 homolog

UniProt data

UniProt name: SEZ6_HUMAN (Q53EL9)

Gene name: SEZ6

Organism: Homo sapiens (Human).

Function: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized on dendrites and in the synaptic and postsynaptic fraction. {ECO:0000250}.

Transmembrane domains:

  1. 926-946, 21 AA, Helical. {ECO:0000255}.

Sequence: 994 AA

10 20 30 40 50 60 MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT 70 80 90 100 110 120 APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT 130 140 150 160 170 180 SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA 190 200 210 220 230 240 WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT 250 260 270 280 290 300 PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV 310 320 330 340 350 360 EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP 370 380 390 400 410 420 RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIAACGGVI 430 440 450 460 470 480 RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE 490 500 510 520 530 540 APPVYDSYEV EYLPIEGLLS SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG 550 560 570 580 590 600 NFSSSTPTYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS 610 620 630 640 650 660 AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD GDDLTARVLG 670 680 690 700 710 720 QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW 730 740 750 760 770 780 KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS 790 800 810 820 830 840 RRLISSPKFP VGATVQYICD QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG 850 860 870 880 890 900 LSAPENGARS PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL 910 920 930 940 950 960 DGFYNSRSLD VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR LQGKSSLQLP 970 980 990 RPRPRPYNRI TIESAFDNPT YETGSLSFAG DERI

CATM prediction

The sequence of SEZ6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         930       940       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 AAHIAAAIFLALVAMVLLVGGVYFYFS 7.2 -47.6° 0.0 37.8 -14.2
Prolines* AAHIAAAIFLPLVAMVLLVGGVYFYFS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 942, GLY, HA1 A, 939, LEU, O 3.48Å
B, 943, GLY, HA2 A, 942, GLY, O 3.40Å
A, 942, GLY, HA1 B, 939, LEU, O 3.48Å
A, 943, GLY, HA2 B, 942, GLY, O 3.40Å