CATM - Q4ZG55: Protein GREB1

UniProt data

Gene name: GREB1; Synonyms=KIAA0575

Organism: Homo sapiens (Human).

Function: May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

1868-1888, 21 AA, Helical. {ECO:0000255}.

Sequence: 1949 AA

10 20 30 40 50 60 MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA LEGGSRVDNE 70 80 90 100 110 120 EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD LRLVSISNEP MDVPAGFLLV 130 140 150 160 170 180 GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL LGFSGNCVGC GKKGFCYFTE FSNHINLKLT 190 200 210 220 230 240 TQPKKQKHLK YYLVRNAQGT LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS 250 260 270 280 290 300 EPVPGTNPSI LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL 310 320 330 340 350 360 GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG LVGPASVTFP 370 380 390 400 410 420 VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND VVVSPLLYTC YQNSQSVSRA 430 440 450 460 470 480 YEQYGASAIQ PISEEMQLLL TVYYLVQLAA DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ 490 500 510 520 530 540 APPQPFPPAP SAAAPVTSAQ LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK 550 560 570 580 590 600 LAKTNYVVII CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG 610 620 630 640 650 660 AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC TSYNLEPHSI 670 680 690 700 710 720 RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI PPSEVTYQQT LLHVWHSGVL 730 740 750 760 770 780 LELGLKKEHM TKQRVEQYVL KLDTEAQTKF KAFLQNSFQN PHTLFVLIHD HAHWDLVSST 790 800 810 820 830 840 VHNLYSQSDP SVGLVDRLLN CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS 850 860 870 880 890 900 CSNGVDLYHE NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT 910 920 930 940 950 960 FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV LLRVPCSPLA 970 980 990 1000 1010 1020 VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ LRMWQKIEDV EWRPQTYLEL 1030 1040 1050 1060 1070 1080 EGLPCILIFS GMDPHGESLP RSLRYCDLRL INSSCLVRTA LEQELGLAAY FVSNEVPLEK 1090 1100 1110 1120 1130 1140 GARNEALESD AEKLSSTDNE DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA 1150 1160 1170 1180 1190 1200 LGGESSAQPT ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP 1210 1220 1230 1240 1250 1260 DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT KACRQPPIVF 1270 1280 1290 1300 1310 1320 LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS KTMTSTEQSL YYRQWTVPRP 1330 1340 1350 1360 1370 1380 SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI 1390 1400 1410 1420 1430 1440 NINLREESDW HYLQLSDPWP DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS 1450 1460 1470 1480 1490 1500 RKPEDLYVRR QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG 1510 1520 1530 1540 1550 1560 EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT TGRHEHGLFN 1570 1580 1590 1600 1610 1620 LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF NSAGVGAAHF LIKELSYHNL 1630 1640 1650 1660 1670 1680 ELERNRQEEL GIKPQDIWPF IVISDDSCVM WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ 1690 1700 1710 1720 1730 1740 HIEAAPDIMH YALLGLRKWS SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC 1750 1760 1770 1780 1790 1800 DDVDFNLRVH SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD 1810 1820 1830 1840 1850 1860 SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI SVCYVSSRPH 1870 1880 1890 1900 1910 1920 SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC VICQDRSSLR QTVVRLELED 1930 1940 EWQFRLRDEF QTANAREDRP LFFLTGRHI

CATM prediction

The sequence of GREB1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

#	Sequence and interface	d	θ	Z'	ω'	Score
	1870 1880 18 + \| + \| + \|	(Å)	(°)	(Å)	(°)
Model 1	SCSDLLFSGLLLYLCDSFVGASFLKKF	6.8	-53.8°	3.6	34.8	-11.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:

Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor	Acceptor	Distance
B, 1877, TYR, HA	A, 1880, ASP, OD2	3.06Å
B, 1881, SER, HA	A, 1880, ASP, O	3.02Å
B, 1884, GLY, HA1	A, 1881, SER, O	2.97Å
A, 1877, TYR, HA	B, 1880, ASP, OD2	3.06Å
A, 1881, SER, HA	B, 1880, ASP, O	3.02Å
A, 1884, GLY, HA1	B, 1881, SER, O	2.97Å