Cell adhesion molecule-related/down-regulated by oncogenes

UniProt data

UniProt name: CDON_HUMAN (Q4KMG0)

Gene name: CDON; Synonyms=CDO

Organism: Homo sapiens (Human).

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 964-984, 21 AA, Helical. {ECO:0000255}.

Sequence: 1287 AA

10 20 30 40 50 60 MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC SAQPVTTRIS 70 80 90 100 110 120 WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN NSIGAIVSGP ATVSVAVLGD 130 140 150 160 170 180 FGSSTKHVIT AEEKSAGFIG CRVPESNPKA EVRYKIRGKW LEHSTENYLI LPSGNLQILN 190 200 210 220 230 240 VSLEDKGSYK CAAYNPVTHQ LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT 250 260 270 280 290 300 LECVVSGVPA PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK 310 320 330 340 350 360 YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ PIHPSARHLT 370 380 390 400 410 420 AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND GGFKPVIITA PVSAKVADGD 430 440 450 460 470 480 FVTLSCNASG LPVPVIRWYD SHGLITSHPS QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA 490 500 510 520 530 540 GASSLHIQAV TQEHAGKYIC EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR 550 560 570 580 590 600 SKRDGSETGL LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA 610 620 630 640 650 660 GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL YEVLMVARSA 670 680 690 700 710 720 AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS EAANNNFGVV LTDSSRHSGV 730 740 750 760 770 780 PEAPDRPTIS TASETSVYVT WIPRANGGSP ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV 790 800 810 820 830 840 EVRSLEPGST YKFRVIAINH YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD 850 860 870 880 890 900 TQIMLKWTYI PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY 910 920 930 940 950 960 DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG NVGPATSPAR 970 980 990 1000 1010 1020 SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY DPPGYLYQGS DMNGQMVDYT 1030 1040 1050 1060 1070 1080 TLSGASQING NVHGGFLTNG GLSSGYSHLH HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT 1090 1100 1110 1120 1130 1140 HVDFEHPHHL VNGGGMYTAV PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA 1150 1160 1170 1180 1190 1200 PYPQDGLEMK PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD 1210 1220 1230 1240 1250 1260 GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN ALILPPVPEG 1270 1280 CAEKTMWSPP GIPLDSPTEV LQQPRET

CATM prediction

The sequence of CDON_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           970       980     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 SSDMLYLIVGCVLGVMVLILMVFIAMC 7.3 -29.9° 4.6 39.1 -25.0
Model 2 SSDMLYLIVGCVLGVMVLILMVFIAMC 6.9 -51.8° 1.4 56.9 -19.8
Model 3 SSDMLYLIVGCVLGVMVLILMVFIAMC 7.2 -49.0° 3.9 37.9 -0.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 967, LEU, HA A, 966, TYR, O 3.18Å
B, 970, GLY, HA1 A, 967, LEU, O 3.47Å
A, 967, LEU, HA B, 966, TYR, O 3.18Å
A, 970, GLY, HA1 B, 967, LEU, O 3.47Å