Scavenger receptor cysteine-rich domain-containing protein SCART1

UniProt data

UniProt name: SRCRM_HUMAN (Q4G0T1)

Gene name: %GENE_NAME%

Organism: Homo sapiens (Human).

Function: May play a role in the immune system, perhaps as a co- receptor on alphabeta and gammadelta T-cells. {ECO:0000269|PubMed:22795646}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 907-927, 21 AA, Helical. {ECO:0000255}.

Sequence: 1027 AA

10 20 30 40 50 60 MRAALWTLGL GPLLLNLWAV PIGGPGALRL AYRHSTCDGV VLVRHHGAWG YVCNQEWTLA 70 80 90 100 110 120 EASVVCRQLG CGPAVGAPKY VPLPGEMAQP WLHNVSCRGN ESSLWECSLG SWCQSPCPHA 130 140 150 160 170 180 WVVVALCSNG TFRELRLVKG RSPCAGLPEI RNVNGVDRLC VLHVEEAMVF CRELGCGPVL 190 200 210 220 230 240 QAPRRDVGVV RKYLACRGTE PTIRSCRLDN NFRSGCDLRL DAEVVCSGHT EARLVGGEHP 250 260 270 280 290 300 CAGRLEVTWG TVCDAALDLA TAHVVCRELQ CGAVVSTPEG ARFGRGSGPV WTEAFRCAGN 310 320 330 340 350 360 ESLLFHCPRG RGSQCGHGHD AGLRCSEFRM VNGSSSCEGR VEFQVQGSWA PLCATHWDIA 370 380 390 400 410 420 DATVLCHQLN CGNAVAAPGG GHFGDGDAAI WPDAFHCEGT ESYLWNCPVS TLGAPACAPG 430 440 450 460 470 480 NTASAVCSGL AHALRLREGQ SRCDGRVEVS LDGVWGRVLD DAWDLRGAGV VCRQLGCRGA 490 500 510 520 530 540 QQAYDAPAPS RGSVQVALSR VRCLGTETRL TQCNVSATLQ EPAGTSRDAG VVCSGEVGTA 550 560 570 580 590 600 SPMARRHGIP GALTLSLHRE PQGAAGRGAG ALHGGAWGTV CDDAWDLRDA HVVCRQLGCG 610 620 630 640 650 660 RALSALGAAH FGAGAGRIWL DELGCQGHES ALWQCPSAGW GRHDWRHKED AGVFCSESVA 670 680 690 700 710 720 LRLRGGTCCC AGWLDVFYNG TWGAMCSNAL KDLSLSIICK QLGCGVWGVG LAGEQALPLC 730 740 750 760 770 780 GHRDRLGGQH RVPQAAQLHS VAMPFPPMAP ALLRPSRAGL SEDRPQAAGE PLNCSSWLGC 790 800 810 820 830 840 PEEGALRVRG GEDRCSGRVE LWHAGSWGTV CDDGWDLADA EVVCRQLGCG RAVAALGAAA 850 860 870 880 890 900 FGPGSGPVWL DEVGCRGSEA SLWGCPAERW GRGDRAHEED AGVRCWEPGP GPPLPAAPFR 910 920 930 940 950 960 TFWVVSVVLG SLLGLLLLGL MAFLILPRVT QAMQRGLGRS EVSPGEAIYD VIGEMPPAGL 970 980 990 1000 1010 1020 YEEIMEAEAV LQDEEDGSVV KVDTEAAVSG EVSNLLEGQS IRAEGGHSRP VSQGYDEAAF PLEEMTL

CATM prediction

The sequence of SRCRM_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        910       920       9
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 VVSVVLGSLLGLLLLGLMAFLILARVT 7.0 -29.0° 2.5 60.0 -15.9
Model 2 VVSVVLGSLLGLLLLGLMAFLILARVT 6.9 -52.1° 1.4 57.2 -11.3
Prolines* VVSVVLGSLLGLLLLGLMAFLILPRVT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 910, GLY, HA1 A, 907, VAL, O 3.44Å
A, 910, GLY, HA1 B, 907, VAL, O 3.44Å