RAB6A-GEF complex partner protein 1 {ECO:0000312|HGNC:HGNC:17686}

UniProt data

UniProt name: RIC1_HUMAN (Q4ADV7)

Gene name: RIC1 {ECO:0000312|HGNC:HGNC:17686}; Synonyms=CIP150, KIAA1432

Organism: Homo sapiens (Human).

Function: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056}.

Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23091056}. Membrane {ECO:0000269|PubMed:23091056}; Single-pass membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 1267-1287, 21 AA, Helical. {ECO:0000255}.

Sequence: 1423 AA

10 20 30 40 50 60 MYFLSGWPKR LLCPLGSPAE APFHVQSDPQ RAFFAVLAAA RLSIWYSRPS VLIVTYKEPA 70 80 90 100 110 120 KSSTQFGSYK QAEWRPDSTM IAVSTANGYI LFFHITSTRG DKYLYEPVYP KGSPQMKGTP 130 140 150 160 170 180 HFKEEQCAPA LNLEMRKILD LQAPIMSLQS VLEDLLVATS DGLLHLIHWE GMTNGRKAIN 190 200 210 220 230 240 LCTVPFSVDL QSSRVGSFLG FTDVHIRDME YCATLDGFAV VFNDGKVGFI TPVSSRFTAE 250 260 270 280 290 300 QLHGVWPQDV VDGTCVAVNN KYRLMAFGCV SGSVQVYTID NSTGAMLLSH KLELTAKQYP 310 320 330 340 350 360 DIWNKTGAVK LMRWSPDNSV VIVTWEYGGL SLWSVFGAQL ICTLGGDFAY RSDGTKKDPL 370 380 390 400 410 420 KINSMSWGAE GYHLWVISGF GSQNTEIESD LRSVVKQPSI LLFQFIKSVL TVNPCMSNQE 430 440 450 460 470 480 QVLLQGEDRL YLNCGEASQT QNPRSSSTHS EHKPSREKSP FADGGLESQG LSTLLGHRHW 490 500 510 520 530 540 HVVQISSTYL ESNWPIRFSA IDKLGQNIAV VGKFGFAHYS LLTKKWKLFG NITQEQNMIV 550 560 570 580 590 600 TGGLAWWNDF MVLACYNIND RQEELRVYLR TSNLDNAFAH VTKAQAETLL LSVFQDMVIV 610 620 630 640 650 660 FRADCSICLY SIERKSDGPN TTAGIQVLQE VSMSRYIPHP FLVVSVTLTS VSTENGITLK 670 680 690 700 710 720 MPQQARGAES IMLNLAGQLI MMQRDRSGPQ IREKDSNPNN QRKLLPFCPP VVLAQSVENV 730 740 750 760 770 780 WTTCRANKQK RHLLEALWLS CGGAGMKVWL PLFPRDHRKP HSFLSQRIML PFHINIYPLA 790 800 810 820 830 840 VLFEDALVLG AVNDTLLYDS LYTRNNAREQ LEVLFPFCVV ERTSQIYLHH ILRQLLVRNL 850 860 870 880 890 900 GEQALLLAQS CATLPYFPHV LELMLHEVLE EEATSREPIP DPLLPTVAKF ITEFPLFLQT 910 920 930 940 950 960 VVHCARKTEY ALWNYLFAAV GNPKDLFEEC LMAQDLDTAA SYLIILQNME VPAVSRQHAT 970 980 990 1000 1010 1020 LLFNTALEQG KWDLCRHMIR FLKAIGSGES ETPPSTPTAQ EPSSSGGFEF FRNRSISLSQ 1030 1040 1050 1060 1070 1080 SAENVPASKF SLQKTLSMPS GPSGKRWSKD SDCAENMYID MMLWRHARRL LEDVRLKDLG 1090 1100 1110 1120 1130 1140 CFAAQLGFEL ISWLCKERTR AARVDNFVIA LKRLHKDFLW PLPIIPASSI SSPFKNGKYR 1150 1160 1170 1180 1190 1200 TVGEQLLKSQ SADPFLNLEM DAGISNIQRS QSWLSNIGPT HHEIDTASSH GPQMQDAFLS 1210 1220 1230 1240 1250 1260 PLSNKGDECS IGSATDLTES SSMVDGDWTM VDENFSTLSL TQSELEHISM ELASKGPHKS 1270 1280 1290 1300 1310 1320 QVQLRYLLHI FMEAGCLDWC IVIGLILRES SIINQILVIT QSSEVDGEML QNIKTGLHAV 1330 1340 1350 1360 1370 1380 DRWASTDCPG YKPFLNIIKP QLQKLSEITE EQVQPDAFQP ITMGKTPEQT SPRAEESRGS 1390 1400 1410 1420 SSHGSIPQGE VGSSNMVSRK EEDTAQAEEE EPFQDGTYDC SVS

CATM prediction

The sequence of RIC1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        1270      1280      1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 LRYLLHIFMEAGCLDWCIVIGLILRES 7.1 -55.0° 2.4 47.8 -22.5
Model 2 LRYLLHIFMEAGCLDWCIVIGLILRES 7.3 -43.6° 1.8 45.4 -11.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1281, ILE, HA A, 1280, CYS, O 3.34Å
B, 1284, GLY, HA1 A, 1281, ILE, O 3.04Å
A, 1281, ILE, HA B, 1280, CYS, O 3.34Å
A, 1284, GLY, HA1 B, 1281, ILE, O 3.04Å