T-cell immunoreceptor with Ig and ITIM domains

UniProt data

UniProt name: TIGIT_HUMAN (Q495A1)

Gene name: TIGIT; Synonyms=VSIG9, VSTM3

Organism: Homo sapiens (Human).

Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.

Transmembrane domains:

  1. 142-162, 21 AA, Helical. {ECO:0000255}.

Sequence: 244 AA

10 20 30 40 50 60 MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE 70 80 90 100 110 120 QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG 130 140 150 160 170 180 RIFLEVLESS VAEHGARFQI PLLGAMAATL VVICTAVIVV VALTRKKKAL RIHSVEGDLR 190 200 210 220 230 240 RKSAGQEEWS PSAPSPPGSC VQAEAAPAGL CGEQRGEDCA ELHDYFNVLS YRSLGNCSFF TETG

CATM prediction

The sequence of TIGIT_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   140       150       160   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 QIALLGAMAATLVVICTAVIVVVALTR 6.8 -47.0° 1.4 45.0 -3.9
Prolines* QIPLLGAMAATLVVICTAVIVVVALTR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 145, ALA, HA A, 144, GLY, O 3.05Å
A, 145, ALA, HA B, 144, GLY, O 3.05Å