Mitochondrial import inner membrane translocase subunit TIM50

UniProt data

UniProt name: TIM50_HUMAN (Q3ZCQ8)

Gene name: TIMM50; Synonyms=TIM50; ORFNames=PRO1512

Organism: Homo sapiens (Human).

Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:15044455}.

Subcellular location: Isoform 2: Nucleus speckle. Note=Nuclear and enriched in speckles with snRNPs.

Transmembrane domains:

  1. 66-86, 21 AA, Helical. {ECO:0000255}.

Sequence: 353 AA

10 20 30 40 50 60 MAASAAVFSR LRSGLRLGSR GLCTRLATPP RRAPDQAAEI GSRGSTKAQG PQQQPGSEGP 70 80 90 100 110 120 SYAKKVALWL AGLLGAGGTV SVVYIFGNNP VDENGAKIPD EFDNDPILVQ QLRRTYKYFK 130 140 150 160 170 180 DYRQMIIEPT SPCLLPDPLQ EPYYQPPYTL VLELTGVLLH PEWSLATGWR FKKRPGIETL 190 200 210 220 230 240 FQQLAPLYEI VIFTSETGMT AFPLIDSVDP HGFISYRLFR DATRYMDGHH VKDISCLNRD 250 260 270 280 290 300 PARVVVVDCK KEAFRLQPYN GVALRPWDGN SDDRVLLDLS AFLKTIALNG VEDVRTVLEH 310 320 330 340 350 YALEDDPLAA FKQRQSRLEQ EEQQRLAELS KSNKQNLFLG SLTSRLWPRS KQP

CATM prediction

The sequence of TIM50_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         70        80        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 AKKVALWLAGLLGAGGTVSVVYIFGNN 6.8 -45.0° 4.0 38.9 -15.9
Model 2 AKKVALWLAGLLGAGGTVSVVYIFGNN 7.2 -40.4° 2.7 33.2 -7.3
Model 3 AKKVALWLAGLLGAGGTVSVVYIFGNN 7.3 -48.0° 0.7 54.2 -6.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 72, GLY, HA2 A, 71, ALA, O 2.72Å
B, 75, GLY, HA1 A, 72, GLY, O 2.85Å
B, 76, ALA, HA A, 79, THR, OG1 2.50Å
A, 72, GLY, HA2 B, 71, ALA, O 2.72Å
A, 75, GLY, HA1 B, 72, GLY, O 2.85Å
A, 76, ALA, HA B, 79, THR, OG1 2.50Å