UDP-glucuronosyltransferase 3A2

UniProt data

UniProt name: UD3A2_HUMAN (Q3SY77)

Gene name: UGT3A2; ORFNames=PSEC0073, UNQ842/PRO1780

Organism: Homo sapiens (Human).

Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 484-504, 21 AA, Helical. {ECO:0000255}.

Sequence: 523 AA

10 20 30 40 50 60 MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG HNVTMLNHKR 70 80 90 100 110 120 GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET LGGRGKFENL LNVLEYLALQ 130 140 150 160 170 180 CSHFLNRKDI MDSLKNENFD MVIVETFDYC PFLIAEKLGK PFVAILSTSF GSLEFGLPIP 190 200 210 220 230 240 LSYVPVFRSL LTDHMDFWGR VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL 250 260 270 280 290 300 LLKAELWFIN SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL 310 320 330 340 350 360 GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD WLPQSDLLAH 370 380 390 400 410 420 PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR VEAKKFGVSI QLKKLKAETL 430 440 450 460 470 480 ALKMKQIMED KRYKSAAVAA SVILRSHPLS PTQRLVGWID HVLQTGGATH LKPYVFQQPW 490 500 510 520 HEQYLLDVFV FLLGLTLGTL WLCGKLLGMA VWWLRGARKV KET

CATM prediction

The sequence of UD3A2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           490       500     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 HEQYLLDVFVFLLGLTLGTLWLCGKLL 7.5 -46.0° 2.7 47.2 -8.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 491, PHE, HA A, 490, VAL, O 3.49Å
B, 494, GLY, HA1 A, 491, PHE, O 3.45Å
A, 491, PHE, HA B, 490, VAL, O 3.49Å
A, 494, GLY, HA1 B, 491, PHE, O 3.45Å