Hereditary hemochromatosis protein

UniProt data

UniProt name: HFE_HUMAN (Q30201)

Gene name: HFE; Synonyms=HLAH

Organism: Homo sapiens (Human).

Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. {ECO:0000269|PubMed:9465039}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:9465039}; Single-pass type I membrane protein {ECO:0000305|PubMed:8696333}.

Transmembrane domains:

  1. 307-330, 24 AA, Helical. {ECO:0000255}.

Sequence: 348 AA

10 20 30 40 50 60 MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF 70 80 90 100 110 120 YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV 130 140 150 160 170 180 ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR 190 200 210 220 230 240 AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL 250 260 270 280 290 300 KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS 310 320 330 340 PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE

CATM prediction

The sequence of HFE_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        310       320       330 
 +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TLVIGVISGIAVFVVILFIGILFIILRKRQ 6.9 -54.0° 3.6 48.9 -22.8
Model 2 TLVIGVISGIAVFVVILFIGILFIILRKRQ 7.4 -36.0° 3.6 36.0 -16.8
Model 3 TLVIGVISGIAVFVVILFIGILFIILRKRQ 7.4 -50.0° 2.9 47.0 -10.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 309, VAL, HA A, 308, GLY, O 2.89Å
B, 312, GLY, HA1 A, 309, VAL, O 3.00Å
A, 309, VAL, HA B, 308, GLY, O 2.89Å
A, 312, GLY, HA1 B, 309, VAL, O 3.00Å