UniProt data
UniProt name: PRTG_HUMAN (Q2VWP7)
Gene name: PRTG {ECO:0000312|HGNC:HGNC:26373}
Organism: Homo sapiens (Human).
Function: May play a role in anteroposterior axis elongation. {ECO:0000250|UniProtKB:Q2EY15}.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Transmembrane domains:
- 950-970, 21 AA, Helical. {ECO:0000255}.
Sequence: 1150 AA
10 20 30 40 50 60
MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC
70 80 90 100 110 120
QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG
130 140 150 160 170 180
AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD
190 200 210 220 230 240
RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG
250 260 270 280 290 300
PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG
310 320 330 340 350 360
VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW
370 380 390 400 410 420
LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS
430 440 450 460 470 480
APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII
490 500 510 520 530 540
DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI
550 560 570 580 590 600
PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG
610 620 630 640 650 660
ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ
670 680 690 700 710 720
QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP
730 740 750 760 770 780
PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM
790 800 810 820 830 840
LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW
850 860 870 880 890 900
KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
910 920 930 940 950 960
VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT
970 980 990 1000 1010 1020
CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP
1030 1040 1050 1060 1070 1080
MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP
1090 1100 1110 1120 1130 1140
GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS
SVISTTPPNL
CATM prediction
The sequence of PRTG_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 950 960 970 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SMTGIAVGVGIALTCILICVLILIYRS | 6.4 | -47.2° | 3.3 | 54.3 | -33.9 |
| Model 2 | SMTGIAVGVGIALTCILICVLILIYRS | 7.3 | -27.0° | 6.0 | 58.0 | -24.2 |
| Model 3 | SMTGIAVGVGIALTCILICVLILIYRS | 7.2 | -45.9° | 2.7 | 46.9 | -21.1 |
| Model 4 | SMTGIAVGVGIALTCILICVLILIYRS | 7.1 | -55.0° | 5.8 | 47.0 | -9.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 951, ILE, HA | A, 950, GLY, O | 2.43Å |
| B, 954, GLY, HA1 | A, 951, ILE, O | 2.56Å |
| B, 955, VAL, HA | A, 954, GLY, O | 3.44Å |
| A, 951, ILE, HA | B, 950, GLY, O | 2.43Å |
| A, 954, GLY, HA1 | B, 951, ILE, O | 2.56Å |
| A, 955, VAL, HA | B, 954, GLY, O | 3.44Å |
