WSC domain-containing protein 2

UniProt data

UniProt name: WSCD2_HUMAN (Q2TBF2)

Gene name: WSCD2; Synonyms=KIAA0789

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 19-41, 23 AA, Helical. {ECO:0000255}.

Sequence: 565 AA

10 20 30 40 50 60 MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE 70 80 90 100 110 120 GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV 130 140 150 160 170 180 REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY 190 200 210 220 230 240 CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP 250 260 270 280 290 300 DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC 310 320 330 340 350 360 AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL 370 380 390 400 410 420 IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN 430 440 450 460 470 480 PYKALMAEFN RKYGGHIGFA AHAHWKGKEW PEFVRNYAPW WATHTLDWLK FGKKVLVVHF 490 500 510 520 530 540 EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS 550 560 AYIKMVDAAL KGRNLTGVPD DYYPR

CATM prediction

The sequence of WSCD2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      20        30        40   
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 AVRFFTFLALYLTAGSLVFLHSGFVGQAA 7.2 -53.0° 1.9 45.0 -3.4
Prolines* PVRFFTFLALYLTAGSLVFLHSGFVGQPA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 27, LEU, HA A, 26, TYR, O 3.47Å
B, 30, GLY, HA1 A, 27, LEU, O 3.11Å
A, 27, LEU, HA B, 26, TYR, O 3.47Å
A, 30, GLY, HA1 B, 27, LEU, O 3.11Å