Leucine-rich repeat-containing protein 26

UniProt data

UniProt name: LRC26_HUMAN (Q2I0M4)

Gene name: LRRC26; Synonyms=CAPC

Organism: Homo sapiens (Human).

Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. {ECO:0000269|PubMed:20613726, ECO:0000269|PubMed:22547800}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}.

Transmembrane domains:

  1. 262-282, 21 AA, Helical. {ECO:0000255}.

Sequence: 334 AA

10 20 30 40 50 60 MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV PGGLASCSAL 70 80 90 100 110 120 SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL DLRENGLHSV HVRAFWGLGA 130 140 150 160 170 180 LQLLDLSANQ LEALAPGTFA PLRALRNLSL AGNRLARLEP AALGALPLLR SLSLQDNELA 190 200 210 220 230 240 ALAPGLLGRL PALDALHLRG NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS 250 260 270 280 290 300 PLTAFSDAAF SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA 310 320 330 ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA

CATM prediction

The sequence of LRC26_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   260       270       280   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LRDLAVVYTLGAASFLVSLASCLALGS 7.1 -53.0° 2.0 45.2 -14.8
Prolines* LRDLAVVYTLGPASFLVSLASCLALGS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 266, TYR, HA A, 265, VAL, O 3.44Å
B, 269, GLY, HA1 A, 266, TYR, O 3.08Å
A, 266, TYR, HA B, 265, VAL, O 3.44Å
A, 269, GLY, HA1 B, 266, TYR, O 3.08Å