Endothelial cell-specific chemotaxis regulator

UniProt data

UniProt name: ECSCR_HUMAN (Q19T08)

Gene name: ECSCR; Synonyms=ECSM2

Organism: Homo sapiens (Human).

Function: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Transmembrane domains:

  1. 125-145, 21 AA, Helical. {ECO:0000255}.

Sequence: 205 AA

10 20 30 40 50 60 MGTAGAMQLC WVILGFLLFR GHNSQPTMTQ TSSSQGGLGG LSLTTEPVSS NPGYIPSSEA 70 80 90 100 110 120 NRPSHLSSTG TPGAGVPSSG RDGGTSRDTF QTVPPNSTTM SLSMREDATI LPSPTSETVL 130 140 150 160 170 180 TVAAFGVISF IVILVVVVII LVGVVSLRFK CRKSKESEDP QKPGSSGLSE SCSTANGEKD 190 200 SITLISMKNI NMNNGKQSLS AEKVL

CATM prediction

The sequence of ECSCR_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          130       140      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 VAAFGVISFIVILVVVVIILVGVVSLR 7.3 -55.0° 4.2 38.0 -10.9

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MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session