MICOS complex subunit MIC60

UniProt data

UniProt name: MIC60_HUMAN (Q16891)

Gene name: IMMT; Synonyms=HMP, MIC60, MINOS2; ORFNames=PIG4, PIG52

Organism: Homo sapiens (Human).

Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:25781180}.

Transmembrane domains:

  1. 46-64, 19 AA, Helical. {ECO:0000255}.

Sequence: 758 AA

10 20 30 40 50 60 MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG 70 80 90 100 110 120 TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE 130 140 150 160 170 180 SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK 190 200 210 220 230 240 PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA 250 260 270 280 290 300 AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE 310 320 330 340 350 360 ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE 370 380 390 400 410 420 LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA 430 440 450 460 470 480 EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR 490 500 510 520 530 540 TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN 550 560 570 580 590 600 TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK 610 620 630 640 650 660 ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL 670 680 690 700 710 720 SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV 730 740 750 AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE

CATM prediction

The sequence of MIC60_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         50        60      
  +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 TGKIAGAGLLFVGGGIGGTILYAKW 6.4 -47.6° 0.5 47.0 -33.7
Model 2 TGKIAGAGLLFVGGGIGGTILYAKW 7.2 -45.9° 2.7 46.9 -22.8
Model 3 TGKIAGAGLLFVGGGIGGTILYAKW 7.3 -47.9° 3.3 34.1 -16.2
Model 4 TGKIAGAGLLFVGGGIGGTILYAKW 6.7 -48.0° 5.1 39.0 -15.4
Model 5 TGKIAGAGLLFVGGGIGGTILYAKW 7.2 -24.0° 3.3 49.0 -12.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 53, PHE, HA A, 52, LEU, O 3.12Å
B, 56, GLY, HA1 A, 53, PHE, O 2.53Å
B, 57, GLY, HA2 A, 56, GLY, O 2.47Å
B, 60, GLY, HA1 A, 57, GLY, O 3.35Å
A, 53, PHE, HA B, 52, LEU, O 3.12Å
A, 56, GLY, HA1 B, 53, PHE, O 2.53Å
A, 57, GLY, HA2 B, 56, GLY, O 2.47Å
A, 60, GLY, HA1 B, 57, GLY, O 3.35Å