Receptor-type tyrosine-protein phosphatase-like N

UniProt data

UniProt name: PTPRN_HUMAN (Q16849)

Gene name: PTPRN; Synonyms=ICA3, ICA512

Organism: Homo sapiens (Human).

Function: ICA512-cleaved cytosolic fragment: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.

Subcellular location: ICA512-cleaved cytosolic fragment: Nucleus {ECO:0000269|PubMed:15596545}.

Transmembrane domains:

  1. 576-600, 25 AA, Helical. {ECO:0000255}.

Sequence: 979 AA

10 20 30 40 50 60 MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG 70 80 90 100 110 120 QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 130 140 150 160 170 180 PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL 190 200 210 220 230 240 LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA 250 260 270 280 290 300 PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG 310 320 330 340 350 360 SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL 370 380 390 400 410 420 LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE 430 440 450 460 470 480 VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP 490 500 510 520 530 540 LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE 550 560 570 580 590 600 LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV 610 620 630 640 650 660 RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ 670 680 690 700 710 720 FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ 730 740 750 760 770 780 AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY 790 800 810 820 830 840 IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV 850 860 870 880 890 900 SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG 910 920 930 940 950 960 RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE 970 FALTAVAEEV NAILKALPQ

CATM prediction

The sequence of PTPRN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         580       590       600 
  +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AMRSVLLTLVALAGVAGLLVALAVALCVRQH 6.8 -45.9° 2.7 47.0 -13.6
Prolines* PMRSVLLTLVALAGVAGLLVALAVALCVRQH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 586, GLY, HA2 A, 585, ALA, O 2.80Å
B, 589, GLY, HA1 A, 586, GLY, O 2.78Å
B, 590, LEU, HA A, 589, GLY, O 3.42Å
A, 586, GLY, HA2 B, 585, ALA, O 2.80Å
A, 589, GLY, HA1 B, 586, GLY, O 2.78Å
A, 590, LEU, HA B, 589, GLY, O 3.42Å