Meprin A subunit alpha

UniProt data

UniProt name: MEP1A_HUMAN (Q16819)

Gene name: MEP1A

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 713-740, 28 AA, Helical. {ECO:0000255}.

Sequence: 746 AA

10 20 30 40 50 60 MAWIRSTCIL FFTLLFAHIA AVPIKYLPEE NVHDADFGEQ KDISEINLAA GLDLFQGDIL 70 80 90 100 110 120 LQKSRNGLRD PNTRWTFPIP YILADNLGLN AKGAILYAFE MFRLKSCVDF KPYEGESSYI 130 140 150 160 170 180 IFQQFDGCWS EVGDQHVGQN ISIGQGCAYK AIIEHEILHA LGFYHEQSRT DRDDYVNIWW 190 200 210 220 230 240 DQILSGYQHN FDTYDDSLIT DLNTPYDYES LMHYQPFSFN KNASVPTITA KIPEFNSIIG 250 260 270 280 290 300 QRLDFSAIDL ERLNRMYNCT TTHTLLDHCT FEKANICGMI QGTRDDTDWA HQDSAQAGEV 310 320 330 340 350 360 DHTLLGQCTG AGYFMQFSTS SGSAEEAALL ESRILYPKRK QQCLQFFYKM TGSPSDRLVV 370 380 390 400 410 420 WVRRDDSTGN VRKLVKVQTF QGDDDHNWKI AHVVLKEEQK FRYLFQGTKG DPQNSTGGIY 430 440 450 460 470 480 LDDITLTETP CPTGVWTVRN FSQVLENTSK GDKLQSPRFY NSEGYGFGVT LYPNSRESSG 490 500 510 520 530 540 YLRLAFHVCS GENDAILEWP VENRQVIITI LDQEPDVRNR MSSSMVFTTS KSHTSPAIND 550 560 570 580 590 600 TVIWDRPSRV GTYHTDCNCF RSIDLGWSGF ISHQMLKRRS FLKNDDLIIF VDFEDITHLS 610 620 630 640 650 660 QTEVPTKGKR LSPQGLILQG QEQQVSEEGS GKAMLEEALP VSLSQGQPSR QKRSVENTGP 670 680 690 700 710 720 LEDHNWPQYF RDPCDPNPCQ NDGICVNVKG MASCRCISGH AFFYTGERCQ AVQVHGSVLG 730 740 MVIGGTAGVI FLTFSIIAIL SQRPRK

CATM prediction

The sequence of MEP1A_HUMAN returned 16 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  710       720       730       740 
|    +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.5 -29.1° 4.6 52.1 -43.9
Model 2 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.4 -41.1° -0.0 45.1 -39.4
Model 3 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.3 -40.5° 3.3 62.1 -35.3
Model 4 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 7.1 -30.0° 1.8 39.0 -32.5
Model 5 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.4 -48.0° 0.5 46.7 -31.0
Model 6 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.6 -39.2° 2.7 43.9 -27.2
Model 7 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.8 -25.0° 5.5 50.0 -25.2
Model 8 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.8 -36.6° 0.3 43.9 -24.1
Model 9 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.9 -47.9° 1.0 37.0 -21.2
Model 10 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.6 -52.3° 5.2 40.0 -21.1
Model 11 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.4 -54.4° 5.0 52.9 -17.8
Model 12 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 7.2 -53.9° 3.6 35.4 -17.0
Model 13 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 7.1 -40.0° 2.7 33.9 -12.9
Model 14 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.6 -55.0° 5.6 39.9 -12.3
Model 15 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 7.0 +51.2° 3.9 72.0 -9.7
Model 16 QAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQR 6.8 -54.7° 0.9 50.1 -5.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 717, SER, HA A, 716, GLY, O 3.14Å
B, 720, GLY, HA1 A, 717, SER, O 2.80Å
B, 721, MET, HA A, 720, GLY, O 2.28Å
B, 724, GLY, HA1 A, 721, MET, O 2.98Å
B, 725, GLY, HA2 A, 724, GLY, O 3.41Å
A, 717, SER, HA B, 716, GLY, O 3.14Å
A, 720, GLY, HA1 B, 717, SER, O 2.80Å
A, 721, MET, HA B, 720, GLY, O 2.28Å
A, 724, GLY, HA1 B, 721, MET, O 2.98Å
A, 725, GLY, HA2 B, 724, GLY, O 3.41Å