Carbonic anhydrase 9

UniProt data

UniProt name: CAH9_HUMAN (Q16790)

Gene name: CA9; Synonyms=G250, MN

Organism: Homo sapiens (Human).

Function: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. {ECO:0000269|PubMed:18703501}.

Subcellular location: Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.

Transmembrane domains:

  1. 415-435, 21 AA, Helical. {ECO:0000255}.

Sequence: 459 AA

10 20 30 40 50 60 MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLVPVHPQRL PRMQEDSPLG GGSSGEDDPL 70 80 90 100 110 120 GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG 130 140 150 160 170 180 DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL 190 200 210 220 230 240 ELLGFQLPPL PELRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT 250 260 270 280 290 300 VEGHRFPAEI HVVHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA 310 320 330 340 350 360 EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS 370 380 390 400 410 420 DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGDILALVF 430 440 450 GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA

CATM prediction

The sequence of CAH9_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          420       430      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 AGDILALVFGLLFAVTSVAFLVQMRRQ 7.1 -38.0° 5.7 34.0 -25.7
Model 2 AGDILALVFGLLFAVTSVAFLVQMRRQ 7.4 -22.0° 3.1 40.0 -5.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 418, LEU, HA A, 417, ALA, O 2.87Å
B, 421, GLY, HA1 A, 418, LEU, O 3.21Å
A, 418, LEU, HA B, 417, ALA, O 2.87Å
A, 421, GLY, HA1 B, 418, LEU, O 3.21Å