Alpha-mannosidase 2

UniProt data

UniProt name: MA2A1_HUMAN (Q16706)

Gene name: MAN2A1; Synonyms=MANA2

Organism: Homo sapiens (Human).

Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 6-26, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 1144 AA

10 20 30 40 50 60 MKLSRQFTVF GSAIFCVVIF SLYLMLDRGH LDYPRNPRRE GSFPQGQLSM LQEKIDHLER 70 80 90 100 110 120 LLAENNEIIS NIRDSVINLS ESVEDGPKSS QSNFSQGAGS HLLPSQLSLS VDTADCLFAS 130 140 150 160 170 180 QSGSHNSDVQ MLDVYSLISF DNPDGGVWKQ GFDITYESNE WDTEPLQVFV VPHSHNDPGW 190 200 210 220 230 240 LKTFNDYFRD KTQYIFNNMV LKLKEDSRRK FIWSEISYLS KWWDIIDIQK KDAVKSLIEN 250 260 270 280 290 300 GQLEIVTGGW VMPDEATPHY FALIDQLIEG HQWLENNIGV KPRSGWAIDP FGHSPTMAYL 310 320 330 340 350 360 LNRAGLSHML IQRVHYAVKK HFALHKTLEF FWRQNWDLGS VTDILCHMMP FYSYDIPHTC 370 380 390 400 410 420 GPDPKICCQF DFKRLPGGRF GCPWGVPPET IHPGNVQSRA RMLLDQYRKK SKLFRTKVLL 430 440 450 460 470 480 APLGDDFRYC EYTEWDLQFK NYQQLFDYMN SQSKFKVKIQ FGTLSDFFDA LDKADETQRD 490 500 510 520 530 540 KGQSMFPVLS GDFFTYADRD DHYWSGYFTS RPFYKRMDRI MESHLRAAEI LYYFALRQAH 550 560 570 580 590 600 KYKINKFLSS SLYTALTEAR RNLGLFQHHD AITGTAKDWV VVDYGTRLFH SLMVLEKIIG 610 620 630 640 650 660 NSAFLLILKD KLTYDSYSPD TFLEMDLKQK SQDSLPQKNI IRLSAEPRYL VVYNPLEQDR 670 680 690 700 710 720 ISLVSVYVSS PTVQVFSASG KPVEVQVSAV WDTANTISET AYEISFRAHI PPLGLKVYKI 730 740 750 760 770 780 LESASSNSHL ADYVLYKNKV EDSGIFTIKN MINTEEGITL ENSFVLLRFD QTGLMKQMMT 790 800 810 820 830 840 KEDGKHHEVN VQFSWYGTTI KRDKSGAYLF LPDGNAKPYV YTTPPFVRVT HGRIYSEVTC 850 860 870 880 890 900 FFDHVTHRVR LYHIQGIEGQ SVEVSNIVDI RKVYNREIAM KISSDIKSQN RFYTDLNGYQ 910 920 930 940 950 960 IQPRMTLSKL PLQANVYPMT TMAYIQDAKH RLTLLSAQSL GVSSLNSGQI EVIMDRRLMQ 970 980 990 1000 1010 1020 DDNRGLEQGI QDNKITANLF RILLEKRSAV NTEEEKKSVS YPSLLSHITS SLMNHPVIPM 1030 1040 1050 1060 1070 1080 ANKFSSPTLE LQGEFSPLQS SLPCDIHLVN LRTIQSKVGN GHSNEAALIL HRKGFDCRFS 1090 1100 1110 1120 1130 1140 SKGTGLFCST TQGKILVQKL LNKFIVESLT PSSLSLMHSP PGTQNISEIN LSPMEISTFR IQLR

CATM prediction

The sequence of MA2A1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         10        20        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 LSRQFTVFGSAIFCVVIFSLYLMLDRG 7.0 -51.1° 2.4 44.9 -10.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, THR, HA A, 7, PHE, O 3.05Å
B, 11, GLY, HA1 A, 8, THR, O 2.82Å
B, 23, TYR, HH A, 23, TYR, OH 2.05Å
A, 8, THR, HA B, 7, PHE, O 3.05Å
A, 11, GLY, HA1 B, 8, THR, O 2.82Å