Tafazzin

UniProt data

UniProt name: TAZ_HUMAN (Q16635)

Gene name: TAZ; Synonyms=EFE2, G4.5

Organism: Homo sapiens (Human).

Function: Some isoforms may be involved in cardiolipin (CL) metabolism. {ECO:0000269|PubMed:12930833, ECO:0000269|PubMed:19164547}.

Subcellular location: Isoform 9: Cytoplasm {ECO:0000305}.

Transmembrane domains:

  1. 1-30, 30 AA, Helical; Signal-anchor. {ECO:0000255}.

Sequence: 292 AA

10 20 30 40 50 60 MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA 70 80 90 100 110 120 TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP 130 140 150 160 170 180 VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR REKGDGVYQK GMDFILEKLN HGDWVHIFPE 190 200 210 220 230 240 GKVNMSSEFL RFKWGIGRLI AECHLNPIIL PLWHVGMNDV LPNSPPYFPR FGQKITVLIG 250 260 270 280 290 KPFSALPVLE RLRAENKSAV EMRKALTDFI QEEFQHLKTQ AEQLHNHLQP GR

CATM prediction

The sequence of TAZ_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           10        20        30  
    +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 MALHVKWAFAAVAALTWTLASSVVMGLVGTYSC 7.2 -41.0° 3.5 37.9 -21.8
Model 2 MALHVKWAFAAVAALTWTLASSVVMGLVGTYSC 7.2 -50.9° 2.4 44.9 -20.2
Model 3 MALHVKWAFAAVAALTWTLASSVVMGLVGTYSC 7.3 -47.0° 3.3 53.9 -1.1
Prolines* MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 26, GLY, HA2 A, 25, MET, O 3.24Å
B, 29, GLY, HA1 A, 26, GLY, O 3.28Å
A, 26, GLY, HA2 B, 25, MET, O 3.24Å
A, 29, GLY, HA1 B, 26, GLY, O 3.28Å