Syntaxin-1A

UniProt data

UniProt name: STX1A_HUMAN (Q16623)

Gene name: STX1A; Synonyms=STX1

Organism: Homo sapiens (Human).

Function: Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. {ECO:0000250|UniProtKB:P32851}.

Subcellular location: Isoform 2: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 266-286, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 288 AA

10 20 30 40 50 60 MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA 70 80 90 100 110 120 ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH 130 140 150 160 170 180 STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG 190 200 210 220 230 240 IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA 250 260 270 280 VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA

CATM prediction

The sequence of STX1A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         270       280      
  +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 RKKIMIIICCVILGIVIASTVGGIFA 6.9 -52.4° 1.3 57.2 -33.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 273, VAL, HA A, 272, CYS, O 3.24Å
B, 276, GLY, HA1 A, 273, VAL, O 2.89Å
B, 277, ILE, HA A, 276, GLY, O 3.41Å
A, 273, VAL, HA B, 272, CYS, O 3.24Å
A, 276, GLY, HA1 B, 273, VAL, O 2.89Å
A, 277, ILE, HA B, 276, GLY, O 3.41Å