NT-3 growth factor receptor

UniProt data

UniProt name: NTRK3_HUMAN (Q16288)

Gene name: NTRK3; Synonyms=TRKC

Organism: Homo sapiens (Human).

Function: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 430-453, 24 AA, Helical. {ECO:0000255}.

Sequence: 839 AA

10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RLFNPSGNDF 730 740 750 760 770 780 CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI 790 800 810 820 830 ECITQGRVLE RPRVCPKEVY DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG

CATM prediction

The sequence of NTRK3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     430       440       450    
   |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 EDTFGVSIAVGLAAFACVLLVVLFVMINKY 7.3 -44.0° 1.8 45.0 -10.7
Model 2 EDTFGVSIAVGLAAFACVLLVVLFVMINKY 7.3 -55.0° 2.4 48.0 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session