V-type proton ATPase subunit S1

UniProt data

UniProt name: VAS1_HUMAN (Q15904)

Gene name: ATP6AP1; Synonyms=ATP6IP1, ATP6S1, VATPS1, XAP3

Organism: Homo sapiens (Human).

Function: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.

Subcellular location: Vacuole membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 420-440, 21 AA, Helical. {ECO:0000255}.

Sequence: 470 AA

10 20 30 40 50 60 MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA 70 80 90 100 110 120 ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE DFTAYGGVFG NKQDSAFSNL 130 140 150 160 170 180 ENALDLAPSS LVLPAVDWYA VSTLTTYLQE KLGASPLHVD LATLRELKLN ASLPALLLIR 190 200 210 220 230 240 LPYTASSGLM APREVLTGND EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAVVAGGL 250 260 270 280 290 300 GRQLLQKQPV SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS 310 320 330 340 350 360 FWNDSFARLS LTYERLFGTT VTFKFILANR LYPVSARHWF TMERLEVHSN GSVAYFNASQ 370 380 390 400 410 420 VTGPSIYSFH CEYVSSLSKK GSLLVARTQP SPWQMMLQDF QIQAFNVMGE QFSYASDCAS 430 440 450 460 FFSPGIWMGL LTSLFMLFIF TYGLHMILSL KTMDRFDDHK GPTISLTQIV

CATM prediction

The sequence of VAS1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     420       430       440 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 DCASFFSAGIWMGLLTSLFMLFIFTYG 6.8 -38.1° 0.4 56.1 -48.7
Model 2 DCASFFSAGIWMGLLTSLFMLFIFTYG 7.0 -55.1° 1.5 44.7 -27.1
Model 3 DCASFFSAGIWMGLLTSLFMLFIFTYG 7.2 -50.9° 1.2 44.9 -24.9
Model 4 DCASFFSAGIWMGLLTSLFMLFIFTYG 6.6 -55.0° 1.6 60.3 -23.7
Prolines* DCASFFSPGIWMGLLTSLFMLFIFTYG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 422, PHE, HA A, 421, PHE, O 3.11Å
B, 425, GLY, HA1 A, 422, PHE, O 3.00Å
B, 426, ILE, HA A, 425, GLY, O 2.91Å
A, 422, PHE, HA B, 421, PHE, O 3.11Å
A, 425, GLY, HA1 B, 422, PHE, O 3.00Å
A, 426, ILE, HA B, 425, GLY, O 2.91Å