UniProt data
UniProt name: EFNB3_HUMAN (Q15768)
EFNB3; Synonyms=EPLG8, LERK8
Homo sapiens (Human).
(Microbial infection) Acts as a receptor for nipah virus and hendra virus. {ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
Membrane; Single-pass type I membrane protein.
- 227-247, 21 AA, Helical. {ECO:0000255}.
340 AA
10 20 30 40 50 60
MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL
70 80 90 100 110 120
LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY
130 140 150 160 170 180
SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP
190 200 210 220 230 240
VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL
250 260 270 280 290 300
GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG
310 320 330
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV
CATM prediction
The sequence of EFNB3_HUMAN returned 8 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # |
Sequence and interface |
d |
θ |
Z' |
ω' |
Score |
| |
230 240 2
+ | + | + | |
(Å) |
(°) |
(Å) |
(°) |
|
| Model 1 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.3 |
-38.1° |
3.1 |
35.2 |
-19.0 |
| Model 2 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.0 |
-26.0° |
3.6 |
54.0 |
-18.3 |
| Model 3 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
6.8 |
-47.9° |
1.0 |
37.1 |
-10.7 |
| Model 4 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.3 |
-51.8° |
0.6 |
48.1 |
-8.3 |
| Model 5 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.0 |
+53.2° |
2.1 |
95.8 |
-6.9 |
| Model 6 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.2 |
-48.0° |
1.0 |
37.3 |
-3.9 |
| Model 7 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.0 |
-48.0° |
3.3 |
34.2 |
-2.2 |
| Model 8 |
SMAAVAGAAGGLALLLLGVAGAGGAMC |
7.1 |
+52.0° |
1.8 |
1.0 |
-1.9 |
| Prolines* |
SMPAVAGAAGGLALLLLGVAGAGGAMC |
|
|
|
|
|
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 238, LEU, HA |
A, 237, LEU, O |
3.43Å |
| B, 241, GLY, HA1 |
A, 238, LEU, O |
3.34Å |
| A, 238, LEU, HA |
B, 237, LEU, O |
3.43Å |
| A, 241, GLY, HA1 |
B, 238, LEU, O |
3.34Å |
MODEL 2 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 230, GLY, HA1 |
A, 227, ALA, O |
3.41Å |
| A, 230, GLY, HA1 |
B, 227, ALA, O |
3.41Å |
MODEL 3 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 230, GLY, HA1 |
A, 227, ALA, O |
2.83Å |
| B, 231, ALA, HA |
A, 230, GLY, O |
3.11Å |
| A, 230, GLY, HA1 |
B, 227, ALA, O |
2.83Å |
| A, 231, ALA, HA |
B, 230, GLY, O |
3.11Å |
MODEL 4 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 241, GLY, HA1 |
A, 238, LEU, O |
3.37Å |
| B, 242, VAL, HA |
A, 241, GLY, O |
3.30Å |
| A, 241, GLY, HA1 |
B, 238, LEU, O |
3.37Å |
| A, 242, VAL, HA |
B, 241, GLY, O |
3.30Å |
MODEL 5 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 244, GLY, HA1 |
A, 240, LEU, O |
3.32Å |
| B, 244, GLY, HA2 |
A, 243, ALA, O |
3.49Å |
| A, 244, GLY, HA1 |
B, 240, LEU, O |
3.32Å |
| A, 244, GLY, HA2 |
B, 243, ALA, O |
3.49Å |
MODEL 6 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 244, GLY, HA1 |
A, 241, GLY, O |
3.22Å |
| B, 245, ALA, HA |
A, 244, GLY, O |
3.20Å |
| A, 244, GLY, HA1 |
B, 241, GLY, O |
3.22Å |
| A, 245, ALA, HA |
B, 244, GLY, O |
3.20Å |
MODEL 7 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 230, GLY, HA2 |
A, 229, ALA, O |
3.17Å |
| B, 233, GLY, HA1 |
A, 230, GLY, O |
3.13Å |
| A, 230, GLY, HA2 |
B, 229, ALA, O |
3.17Å |
| A, 233, GLY, HA1 |
B, 230, GLY, O |
3.13Å |
MODEL 8 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 230, GLY, HA2 |
A, 229, ALA, O |
3.43Å |
| A, 230, GLY, HA2 |
B, 229, ALA, O |
3.43Å |
