Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

UniProt data

UniProt name: NSDHL_HUMAN (Q15738)

Gene name: NSDHL; Synonyms=H105E3

Organism: Homo sapiens (Human).

Function: Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000269|PubMed:14506130}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506130}; Single-pass membrane protein {ECO:0000269|PubMed:14506130}. Lipid droplet {ECO:0000269|PubMed:14506130}. Note=Trafficking through the Golgi is necessary for ER membrane localization.

Transmembrane domains:

  1. 298-318, 21 AA, Helical. {ECO:0000255}.

Sequence: 373 AA

10 20 30 40 50 60 MEPAVSEPMR DQVARTHLTE DTPKVNADIE KVNQNQAKRC TVIGGSGFLG QHMVEQLLAR 70 80 90 100 110 120 GYAVNVFDIQ QGFDNPQVRF FLGDLCSRQD LYPALKGVNT VFHCASPPPS SNNKELFYRV 130 140 150 160 170 180 NYIGTKNVIE TCKEAGVQKL ILTSSASVIF EGVDIKNGTE DLPYAMKPID YYTETKILQE 190 200 210 220 230 240 RAVLGANDPE KNFLTTAIRP HGIFGPRDPQ LVPILIEAAR NGKMKFVIGN GKNLVDFTFV 250 260 270 280 290 300 ENVVHGHILA AEQLSRDSTL GGKAFHITND EPIPFWTFLS RILTGLNYEA PKYHIPYWVA 310 320 330 340 350 360 YYLALLLSLL VMVISPVIQL QPTFTPMRVA LAGTFHYYSC ERAKKAMGYQ PLVTMDDAME 370 RTVQSFRHLR RVK

CATM prediction

The sequence of NSDHL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       300       310       32
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 IAYWVAYYLALLLSLLVMVISAVIQLQ 7.3 -34.0° 2.7 38.0 -2.8
Prolines* IPYWVAYYLALLLSLLVMVISPVIQLQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 301, TYR, HA A, 300, ALA, O 3.44Å
A, 301, TYR, HA B, 300, ALA, O 3.46Å