Mitochondrial import receptor subunit TOM20 homolog

UniProt data

UniProt name: TOM20_HUMAN (Q15388)

Gene name: TOMM20; Synonyms=KIAA0016

Organism: Homo sapiens (Human).

Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). {ECO:0000250}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101}; Single-pass membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 7-24, 18 AA, Helical. {ECO:0000255}.

Sequence: 145 AA

10 20 30 40 50 60 MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE RAGLSKLPDL 70 80 90 100 110 120 KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC GQPQQLLQVL QQTLPPPVFQ 130 140 MLLTKLPTIS QRIVSAQSLA EDDVE

CATM prediction

The sequence of TOM20_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20      
 +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 RNSAIAAGVCGALFIGYCIYFDRK 7.0 -45.6° 2.7 47.1 -8.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, ILE, HA A, 7, ALA, O 3.03Å
B, 11, GLY, HA1 A, 8, ILE, O 2.99Å
A, 8, ILE, HA B, 7, ALA, O 3.03Å
A, 11, GLY, HA1 B, 8, ILE, O 2.99Å
A, 23, TYR, HH B, 23, TYR, OH 2.25Å