Receptor-type tyrosine-protein phosphatase kappa

UniProt data

UniProt name: PTPRK_HUMAN (Q15262)

Gene name: PTPRK; Synonyms=PTPK

Organism: Homo sapiens (Human).

Function: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.

Subcellular location: Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 753-774, 22 AA, Helical. {ECO:0000255}.

Sequence: 1439 AA

10 20 30 40 50 60 MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 70 80 90 100 110 120 SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 130 140 150 160 170 180 GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 190 200 210 220 230 240 AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 250 260 270 280 290 300 AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 310 320 330 340 350 360 LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 370 380 390 400 410 420 IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 430 440 450 460 470 480 HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 490 500 510 520 530 540 TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 550 560 570 580 590 600 AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 610 620 630 640 650 660 GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 670 680 690 700 710 720 AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 730 740 750 760 770 780 TKTQCVRIAT KAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV ILIVKKSKLA 790 800 810 820 830 840 KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES 850 860 870 880 890 900 SRLLDVPRYL CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA 910 920 930 940 950 960 SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ RPSHYIATQG 970 980 990 1000 1010 1020 PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP DDTEVYGDFK VTCVEMEPLA 1030 1040 1050 1060 1070 1080 EYVVRTFTLE RRGYNEIREV KQFHFTGWPD HGVPYHATGL LSFIRRVKLS NPPSAGPIVV 1090 1100 1110 1120 1130 1140 HCSAGAGRTG CYIVIDIMLD MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE 1150 1160 1170 1180 1190 1200 ACLCGETAIP VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN 1210 1220 1230 1240 1250 1260 HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP LPNTVKDFWR 1270 1280 1290 1300 1310 1320 LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE CMSCSMDCDV INRIFRICNL 1330 1340 1350 1360 1370 1380 TRPQEGYLMV QQFQYLGWAS HREVPGSKRS FLKLILQVEK WQEECEEGEG RTIIHCLNGG 1390 1400 1410 1420 1430 GRSGMFCAIG IVVEMVKRQN VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS

CATM prediction

The sequence of PTPRK_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  750       760       770     
|    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VVKIAGISAGILVFILLLLVVILIVKKS 6.8 -54.2° 3.6 49.0 -24.2
Model 2 VVKIAGISAGILVFILLLLVVILIVKKS 7.5 -39.0° 2.7 44.0 -13.8
Model 3 VVKIAGISAGILVFILLLLVVILIVKKS 7.2 -53.0° 1.9 45.0 -8.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 756, ILE, HA A, 755, GLY, O 2.75Å
B, 759, GLY, HA1 A, 756, ILE, O 2.82Å
A, 756, ILE, HA B, 755, GLY, O 2.75Å
A, 759, GLY, HA1 B, 756, ILE, O 2.82Å