UniProt data
UniProt name: NECT1_HUMAN (Q15223)
Gene name: NECTIN1 {ECO:0000312|HGNC:HGNC:9706}; Synonyms=HVEC, PRR1, PVRL1
Organism: Homo sapiens (Human).
Function: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. {ECO:0000269|PubMed:7721102, ECO:0000269|PubMed:9657005}.
Subcellular location: Isoform Gamma: Secreted.
Transmembrane domains:
- 356-376, 21 AA, Helical. {ECO:0000255}.
Sequence: 517 AA
CATM prediction
The sequence of NECT1_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 360 370 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | ATAIIGGVAGSILLVLIVVGGIVVALR | 7.2 | -47.0° | 2.2 | 45.1 | -15.9 |
| Model 2 | ATAIIGGVAGSILLVLIVVGGIVVALR | 7.3 | -52.0° | 0.6 | 47.9 | -15.5 |
| Model 3 | ATAIIGGVAGSILLVLIVVGGIVVALR | 6.4 | -55.0° | 4.2 | 38.1 | -10.6 |
| Prolines* | PTAIIGGVAGSILLVLIVVGGIVVALR |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 359, GLY, HA1 | A, 356, ILE, O | 2.96Å |
| B, 360, VAL, HA | A, 359, GLY, O | 3.40Å |
| B, 363, SER, HG1 | A, 360, VAL, O | 2.65Å |
| A, 359, GLY, HA1 | B, 356, ILE, O | 2.96Å |
| A, 360, VAL, HA | B, 359, GLY, O | 3.40Å |
| A, 363, SER, HG1 | B, 360, VAL, O | 2.65Å |
