Advanced glycosylation end product-specific receptor

UniProt data

UniProt name: RAGE_HUMAN (Q15109)

Gene name: AGER; Synonyms=RAGE

Organism: Homo sapiens (Human).

Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. {ECO:0000250, ECO:0000269|PubMed:19906677, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706}.

Subcellular location: Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.

Transmembrane domains:

  1. 343-363, 21 AA, Helical. {ECO:0000255}.

Sequence: 404 AA

10 20 30 40 50 60 MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA 70 80 90 100 110 120 WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI 130 140 150 160 170 180 PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH 190 200 210 220 230 240 PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL 250 260 270 280 290 300 VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS 310 320 330 340 350 360 CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV 370 380 390 400 ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP

CATM prediction

The sequence of RAGE_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  340       350       360    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 TLALALGILGGLGTAALLIGVILWQRR 7.2 -26.2° 4.5 36.8 -37.4
Model 2 TLALALGILGGLGTAALLIGVILWQRR 7.2 -40.0° 2.7 34.3 -35.1
Model 3 TLALALGILGGLGTAALLIGVILWQRR 6.7 -51.8° 1.3 57.1 -22.2
Model 4 TLALALGILGGLGTAALLIGVILWQRR 6.8 -47.9° 0.7 54.1 -17.8
Model 5 TLALALGILGGLGTAALLIGVILWQRR 7.1 +51.8° 1.8 1.1 -5.5
Model 6 TLALALGILGGLGTAALLIGVILWQRR 7.3 -41.0° 3.5 37.9 -5.5
Model 7 TLALALGILGGLGTAALLIGVILWQRR 6.8 -51.8° 1.8 35.2 -4.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 346, GLY, HA1 A, 343, LEU, O 3.22Å
B, 347, ILE, HA A, 346, GLY, O 3.31Å
A, 346, GLY, HA1 B, 343, LEU, O 3.22Å
A, 347, ILE, HA B, 346, GLY, O 3.31Å