Intercellular adhesion molecule 4

UniProt data

UniProt name: ICAM4_HUMAN (Q14773)

Gene name: ICAM4; Synonyms=LW

Organism: Homo sapiens (Human).

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. {ECO:0000269|PubMed:11435317}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ERM2}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 241-261, 21 AA, Helical. {ECO:0000255}.

Sequence: 271 AA

10 20 30 40 50 60 MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 70 80 90 100 110 120 PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 130 140 150 160 170 180 TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL 190 200 210 220 230 240 ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA 250 260 270 LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

CATM prediction

The sequence of ICAM4_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    240       250       260  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ATALASGSIAALVGILLTVGAAYLCKC 7.1 -40.0° 4.0 38.0 -28.4
Model 2 ATALASGSIAALVGILLTVGAAYLCKC 6.8 -44.0° 1.8 44.8 -19.8
Model 3 ATALASGSIAALVGILLTVGAAYLCKC 7.0 -37.7° 3.2 34.9 -3.3
Prolines* PTALASGSIAALVGILLTVGAAYLCKC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 248, ALA, HA A, 247, ALA, O 3.02Å
B, 251, GLY, HA1 A, 248, ALA, O 3.17Å
B, 252, ILE, HA A, 255, THR, OG1 2.55Å
A, 248, ALA, HA B, 247, ALA, O 3.02Å
A, 251, GLY, HA1 B, 248, ALA, O 3.17Å
A, 252, ILE, HA B, 255, THR, OG1 2.55Å