Interleukin-11 receptor subunit alpha

UniProt data

UniProt name: I11RA_HUMAN (Q14626)

Gene name: IL11RA

Organism: Homo sapiens (Human).

Function: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 371-391, 21 AA, Helical. {ECO:0000255}.

Sequence: 422 AA

10 20 30 40 50 60 MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 70 80 90 100 110 120 RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 130 140 150 160 170 180 QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 190 200 210 220 230 240 VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 250 260 270 280 290 300 TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 310 320 330 340 350 360 AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 370 380 390 400 410 420 DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP NL

CATM prediction

The sequence of I11RA_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    370       380       390  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 VLASLGILSFLGLVAGALALGLWLRLR 6.7 -54.9° 1.5 44.9 -15.9
Model 2 VLASLGILSFLGLVAGALALGLWLRLR 6.4 -55.0° 2.4 47.8 -14.6
Model 3 VLASLGILSFLGLVAGALALGLWLRLR 7.4 -51.1° 3.3 48.5 -9.6
Model 4 VLASLGILSFLGLVAGALALGLWLRLR 7.0 +51.2° 3.9 72.2 -5.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 376, SER, HA A, 375, LEU, O 3.37Å
B, 379, GLY, HA1 A, 376, SER, O 2.74Å
B, 380, LEU, HA A, 379, GLY, O 3.19Å
A, 376, SER, HA B, 375, LEU, O 3.37Å
A, 379, GLY, HA1 B, 376, SER, O 2.74Å
A, 380, LEU, HA B, 379, GLY, O 3.19Å