Peptidyl-prolyl cis-trans isomerase FKBP8

UniProt data

UniProt name: FKBP8_HUMAN (Q14318)

Gene name: FKBP8; Synonyms=FKBP38

Organism: Homo sapiens (Human).

Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

Subcellular location: Isoform 3: Mitochondrion membrane {ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.

Transmembrane domains:

  1. 390-410, 21 AA, Helical. {ECO:0000255}.

Sequence: 412 AA

10 20 30 40 50 60 MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS ELPPLEDMGQ 70 80 90 100 110 120 PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG LLRKKTLVPG PPGSSRPVKG 130 140 150 160 170 180 QVVTVHLQTS LENGTRVQEE PELVFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG 190 200 210 220 230 240 PQGRSPYIPP HAALCLEVTL KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA 250 260 270 280 290 300 ANSYDLAIKA ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE 310 320 330 340 350 360 HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKHAAQRSTE 370 380 390 400 410 TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN

CATM prediction

The sequence of FKBP8_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     390       400       410
   |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 AWKWLFGATAVALGGVALSVVIAARN 7.3 -44.0° 1.8 45.0 -7.0
Model 2 AWKWLFGATAVALGGVALSVVIAARN 7.3 -53.9° 3.6 49.2 -2.6
Prolines* PWKWLFGATAVALGGVALSVVIAARN          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 398, ALA, HA A, 397, VAL, O 3.47Å
B, 401, GLY, HA1 A, 398, ALA, O 3.26Å
B, 405, SER, HG1 A, 402, VAL, O 2.57Å
A, 398, ALA, HA B, 397, VAL, O 3.47Å
A, 401, GLY, HA1 B, 398, ALA, O 3.26Å
A, 405, SER, HG1 B, 402, VAL, O 2.57Å