Malectin

UniProt data

UniProt name: MLEC_HUMAN (Q14165)

Gene name: MLEC; Synonyms=KIAA0152

Organism: Homo sapiens (Human).

Function: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity). {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 270-290, 21 AA, Helical. {ECO:0000255}.

Sequence: 292 AA

10 20 30 40 50 60 MLGAWAVEGT AVALLRLLLL LLPPAIRGPG LGVAGVAGAA GAGLPESVIW AVNAGGEAHV 70 80 90 100 110 120 DVHGIHFRKD PLEGRVGRAS DYGMKLPILR SNPEDQILYQ TERYNEETFG YEVPIKEEGD 130 140 150 160 170 180 YVLVLKFAEV YFAQSQQKVF DVRLNGHVVV KDLDIFDRVG HSTAHDEIIP MSIRKGKLSV 190 200 210 220 230 240 QGEVSTFTGK LYIEFVKGYY DNPKVCALYI MAGTVDDVPK LQPHPGLEKK EEEEEEEEYD 250 260 270 280 290 EGSNLKKQTN KNRVQSGPRT PNPYASDNSS LMFPILVAFG VFIPTLFCLC RL

CATM prediction

The sequence of MLEC_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     270       280       290
   |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 DNSSLMFAILVAFGVFIATLFCLCRL 7.3 -46.8° 1.3 44.7 -12.4
Prolines* DNSSLMFPILVAFGVFIPTLFCLCRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 280, GLY, HA1 A, 277, VAL, O 3.36Å
B, 281, VAL, HA A, 280, GLY, O 3.43Å
A, 280, GLY, HA1 B, 277, VAL, O 3.36Å
A, 281, VAL, HA B, 280, GLY, O 3.43Å