Scavenger receptor class F member 1

UniProt data

UniProt name: SREC_HUMAN (Q14162)

Gene name: SCARF1; Synonyms=KIAA0149, SREC

Organism: Homo sapiens (Human).

Function: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 422-442, 21 AA, Helical. {ECO:0000255}.

Sequence: 830 AA

10 20 30 40 50 60 MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP 70 80 90 100 110 120 DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC 130 140 150 160 170 180 QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV 190 200 210 220 230 240 CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP 250 260 270 280 290 300 PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG 310 320 330 340 350 360 TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ 370 380 390 400 410 420 GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD 430 440 450 460 470 480 TALIAGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST 490 500 510 520 530 540 LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV 550 560 570 580 590 600 PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP 610 620 630 640 650 660 QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA ASPGDSATGH 670 680 690 700 710 720 RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA 730 740 750 760 770 780 EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL 790 800 810 820 GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP

CATM prediction

The sequence of SREC_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   420       430       440   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 RDTALIAGSLVALLLLFLGLACCACCC 7.1 -40.0° 4.5 44.0 -14.3
Model 2 RDTALIAGSLVALLLLFLGLACCACCC 7.4 -47.1° 2.3 44.9 -4.2
Prolines* RDTALIAGSLVPLLLLFLGLACCACCC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 423, LEU, HA A, 422, ALA, O 2.95Å
B, 426, GLY, HA1 A, 423, LEU, O 3.32Å
A, 423, LEU, HA B, 422, ALA, O 2.95Å
A, 426, GLY, HA1 B, 423, LEU, O 3.32Å