Integrin alpha-9

UniProt data

UniProt name: ITA9_HUMAN (Q13797)

Gene name: ITGA9

Organism: Homo sapiens (Human).

Function: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E- I-D-G-I-E-L in cytotactin. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 982-1002, 21 AA, Helical. {ECO:0000255}.

Sequence: 1035 AA

10 20 30 40 50 60 MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT 70 80 90 100 110 120 RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR 130 140 150 160 170 180 DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY 190 200 210 220 230 240 EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM 250 260 270 280 290 300 NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 310 320 330 340 350 360 GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY 370 380 390 400 410 420 NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN 430 440 450 460 470 480 PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP 490 500 510 520 530 540 QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG 550 560 570 580 590 600 QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 610 620 630 640 650 660 RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG AVKNISLNIS 670 680 690 700 710 720 ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE 730 740 750 760 770 780 FSVIFDTSHL SGEEEVLSFI VTAQSGNTER SESLHDNTLV LMVPLMHEVD TSITGIMSPT 790 800 810 820 830 840 SFVYGESVDA ANFIQLDDLE CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM 850 860 870 880 890 900 FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT 910 920 930 940 950 960 AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR VVEIAHGNPE 970 980 990 1000 1010 1020 EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL LWKMGFFRRR YKEIIEAEKN 1030 RKENEDSWDW VQKNQ

CATM prediction

The sequence of ITA9_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   980       990       1000  
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 VGWIIAISLLVGILIFLLLAVLLWKMG 7.3 -54.0° 3.6 49.1 -5.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 983, ILE, HA A, 986, SER, OG 3.10Å
B, 987, LEU, HA A, 986, SER, O 3.28Å
B, 990, GLY, HA1 A, 987, LEU, O 3.42Å
A, 983, ILE, HA B, 986, SER, OG 3.10Å
A, 987, LEU, HA B, 986, SER, O 3.28Å
A, 990, GLY, HA1 B, 987, LEU, O 3.42Å