CD166 antigen

UniProt data

UniProt name: CD166_HUMAN (Q13740)

Gene name: ALCAM; Synonyms=MEMD {ECO:0000303|PubMed:9502422}

Organism: Homo sapiens (Human).

Function: Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}.

Subcellular location: Isoform 3: Secreted {ECO:0000269|PubMed:15496415}.

Transmembrane domains:

  1. 528-549, 22 AA, Helical. {ECO:0000255}.

Sequence: 583 AA

10 20 30 40 50 60 MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK 70 80 90 100 110 120 PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN 130 140 150 160 170 180 VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL 190 200 210 220 230 240 EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF 250 260 270 280 290 300 DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 310 320 330 340 350 360 TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR 370 380 390 400 410 420 NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 430 440 450 460 470 480 TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 490 500 510 520 530 540 VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA 550 560 570 580 LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA

CATM prediction

The sequence of CD166_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       530       540       550
+    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 QAKLIVGIVVGLLLAALVAGVVYWLYMK 6.4 -45.0° 4.4 54.9 -46.2
Model 2 QAKLIVGIVVGLLLAALVAGVVYWLYMK 7.0 -27.8° 2.4 49.9 -37.0
Model 3 QAKLIVGIVVGLLLAALVAGVVYWLYMK 7.0 -40.0° 4.5 44.0 -21.7
Model 4 QAKLIVGIVVGLLLAALVAGVVYWLYMK 7.3 -43.1° 3.0 35.2 -20.2
Model 5 QAKLIVGIVVGLLLAALVAGVVYWLYMK 7.4 -39.1° 1.1 43.0 -12.7
Model 6 QAKLIVGIVVGLLLAALVAGVVYWLYMK 7.3 -54.9° 2.4 47.9 -12.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 531, GLY, HA1 A, 528, LEU, O 3.05Å
B, 532, ILE, HA A, 531, GLY, O 2.28Å
B, 535, GLY, HA1 A, 532, ILE, O 2.75Å
A, 531, GLY, HA1 B, 528, LEU, O 3.05Å
A, 532, ILE, HA B, 531, GLY, O 2.28Å
A, 535, GLY, HA1 B, 532, ILE, O 2.75Å