Mannosyl-oligosaccharide glucosidase

UniProt data

UniProt name: MOGS_HUMAN (Q13724)

Gene name: MOGS; Synonyms=GCS1

Organism: Homo sapiens (Human).

Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 39-59, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 837 AA

10 20 30 40 50 60 MARGERRRRA VPAEGVRTAE RAARGGPGRR DGRGGGPRST AGGVALAVVV LSLALGMSGR 70 80 90 100 110 120 WVLAWYRARR AVTLHSAPPV LPADSSSPAV APDLFWGTYR PHVYFGMKTR SPKPLLTGLM 130 140 150 160 170 180 WAQQGTTPGT PKLRHTCEQG DGVGPYGWEF HDGLSFGRQH IQDGALRLTT EFVKRPGGQH 190 200 210 220 230 240 GGDWSWRVTV EPQDSGTSAL PLVSLFFYVV TDGKEVLLPE VGAKGQLKFI SGHTSELGDF 250 260 270 280 290 300 RFTLLPPTSP GDTAPKYGSY NVFWTSNPGL PLLTEMVKSR LNSWFQHRPP GAPPERYLGL 310 320 330 340 350 360 PGSLKWEDRG PSGQGQGQFL IQQVTLKIPI SIEFVFESGS AQAGGNQALP RLAGSLLTQA 370 380 390 400 410 420 LESHAEGFRE RFEKTFQLKE KGLSSGEQVL GQAALSGLLG GIGYFYGQGL VLPDIGVEGS 430 440 450 460 470 480 EQKVDPALFP PVPLFTAVPS RSFFPRGFLW DEGFHQLVVQ RWDPSLTREA LGHWLGLLNA 490 500 510 520 530 540 DGWIGREQIL GDEARARVPP EFLVQRAVHA NPPTLLLPVA HMLEVGDPDD LAFLRKALPR 550 560 570 580 590 600 LHAWFSWLHQ SQAGPLPLSY RWRGRDPALP TLLNPKTLPS GLDDYPRASH PSVTERHLDL 610 620 630 640 650 660 RCWVALGARV LTRLAEHLGE AEVAAELGPL AASLEAAESL DELHWAPELG VFADFGNHTK 670 680 690 700 710 720 AVQLKPRPPQ GLVRVVGRPQ PQLQYVDALG YVSLFPLLLR LLDPTSSRLG PLLDILADSR 730 740 750 760 770 780 HLWSPFGLRS LAASSSFYGQ RNSEHDPPYW RGAVWLNVNY LALGALHHYG HLEGPHQARA 790 800 810 820 830 AKLHGELRAN VVGNVWRQYQ ATGFLWEQYS DRDGRGMGCR PFHGWTSLVL LAMAEDY

CATM prediction

The sequence of MOGS_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      40        50        60 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GARSTAGGVALAVVVLSLALGMSGRWV 7.3 -42.3° 2.8 49.7 -8.8
Prolines* GPRSTAGGVALAVVVLSLALGMSGRWV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 40, THR, HA A, 39, SER, O 3.13Å
B, 43, GLY, HA1 A, 40, THR, O 3.33Å
A, 40, THR, HA B, 39, SER, O 3.13Å
A, 43, GLY, HA1 B, 40, THR, O 3.33Å