UniProt data
UniProt name: I10R1_HUMAN (Q13651)
Gene name: IL10RA; Synonyms=IL10R
Organism: Homo sapiens (Human).
Function: Receptor for IL10; binds IL10 with a high affinity.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 236-256, 21 AA, Helical. {ECO:0000255}.
Sequence: 578 AA
10 20 30 40 50 60
MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA
70 80 90 100 110 120
LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV
130 140 150 160 170 180
DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF
190 200 210 220 230 240
THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF
250 260 270 280 290 300
AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA
310 320 330 340 350 360
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN REPPVLGDSC
370 380 390 400 410 420
SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS
430 440 450 460 470 480
ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC
490 500 510 520 530 540
LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS
550 560 570
FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE
CATM prediction
The sequence of I10R1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 240 250 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | VTNVIIFFAFVLLLSGALAYCLALQLY | 6.9 | -55.0° | 1.5 | 45.2 | -22.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 245, LEU, HA | A, 244, LEU, O | 3.30Å |
| B, 248, GLY, HA1 | A, 245, LEU, O | 2.78Å |
| B, 249, ALA, HA | A, 248, GLY, O | 3.43Å |
| A, 245, LEU, HA | B, 244, LEU, O | 3.30Å |
| A, 248, GLY, HA1 | B, 245, LEU, O | 2.78Å |
| A, 249, ALA, HA | B, 248, GLY, O | 3.43Å |