Trophoblast glycoprotein

UniProt data

UniProt name: TPBG_HUMAN (Q13641)

Gene name: TPBG; Synonyms=5T4

Organism: Homo sapiens (Human).

Function: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. {ECO:0000269|PubMed:22100263}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.

Transmembrane domains:

  1. 356-376, 21 AA, Helical. {ECO:0000255}.

Sequence: 420 AA

10 20 30 40 50 60 MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD 70 80 90 100 110 120 QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL 130 140 150 160 170 180 AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL 190 200 210 220 230 240 NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD 250 260 270 280 290 300 LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC 310 320 330 340 350 360 HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG 370 380 390 400 410 IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

CATM prediction

The sequence of TPBG_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         360       370       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 QTSYVFLGIVLALIGAIFLLVLYLNRK 7.1 -46.9° 2.2 45.1 -21.2
Model 2 QTSYVFLGIVLALIGAIFLLVLYLNRK 7.2 -48.1° 3.3 33.9 -18.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 357, VAL, HA A, 356, TYR, O 3.20Å
B, 360, GLY, HA1 A, 357, VAL, O 2.95Å
B, 361, ILE, HA A, 360, GLY, O 3.31Å
A, 357, VAL, HA B, 356, TYR, O 3.20Å
A, 360, GLY, HA1 B, 357, VAL, O 2.95Å
A, 361, ILE, HA B, 360, GLY, O 3.31Å