Cadherin-18

UniProt data

UniProt name: CAD18_HUMAN (Q13634)

Gene name: CDH18; Synonyms=CDH14

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 609-636, 28 AA, Helical. {ECO:0000255}.

Sequence: 790 AA

10 20 30 40 50 60 MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF 70 80 90 100 110 120 FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ 130 140 150 160 170 180 KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ 190 200 210 220 230 240 VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD 250 260 270 280 290 300 MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN 310 320 330 340 350 360 ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH 370 380 390 400 410 420 LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF 430 440 450 460 470 480 INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD 490 500 510 520 530 540 VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK 550 560 570 580 590 600 DNEDNTASIL TRRRRFSRTV QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC 610 620 630 640 650 660 HAEAFLSSAG LSTGALIAIL LCVLILLAIV VLFITLRRSK KEPLIISEED VRENVVTYDD 670 680 690 700 710 720 EGGGEEDTEA FDITALRNPS AAEELKYRRD IRPEVKLTPR HQTSSTLESI DVQEFIKQRL 730 740 750 760 770 780 AEADLDPSVP PYDSLQTYAY EGQRSEAGSI SSLDSATTQS DQDYHYLGDW GPEFKKLAEL YGEIESERTT

CATM prediction

The sequence of CAD18_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      610       620       630       
    |    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 LSSAGLSTGALIAILLCVLILLAIVVLFITLRRS 7.2 -23.0° 2.4 46.0 -18.7
Model 2 LSSAGLSTGALIAILLCVLILLAIVVLFITLRRS 6.8 -46.8° 1.3 45.0 -18.7
Model 3 LSSAGLSTGALIAILLCVLILLAIVVLFITLRRS 6.8 -36.0° 0.9 56.0 -13.3
Model 4 LSSAGLSTGALIAILLCVLILLAIVVLFITLRRS 7.0 -49.0° 2.7 62.8 -9.1
Model 5 LSSAGLSTGALIAILLCVLILLAIVVLFITLRRS 7.2 -37.3° 0.0 37.0 -8.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 611, LEU, HA A, 610, GLY, O 3.29Å
A, 611, LEU, HA B, 610, GLY, O 3.29Å