Metaxin-1

UniProt data

UniProt name: MTX1_HUMAN (Q13505)

Gene name: MTX1; Synonyms=MTX, MTXN

Organism: Homo sapiens (Human).

Function: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000250}.

Transmembrane domains:

  1. 421-441, 21 AA, Helical. {ECO:0000255}.

Sequence: 466 AA

10 20 30 40 50 60 MLLGGPPRSP RSGTSPKGPW SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWTRR 70 80 90 100 110 120 RDTPRRAGPT ALSRYVGHLW MGRRPPSPEA RGPVPRSSAA SRARRSLASP GISPGPLTAT 130 140 150 160 170 180 IGGAVAGGGP RQGRAEAHKE VFPGQRVGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR 190 200 210 220 230 240 FTGAPLKVHK ISNPWQSPSG TLPALRTSHG EVISVPHKII THLRKEKYNA DYDLSARQGA 250 260 270 280 290 300 DTLAFMSLLE EKLLPVLVHT FWIDTKNYVE VTRKWYAEAM PFPLNFFLPG RMQRQYMERL 310 320 330 340 350 360 QLLTGEHRPE DEEELEKELY REARECLTLL SQRLGSQKFF FGDAPASLDA FVFSYLALLL 370 380 390 400 410 420 QAKLPSGKLQ VHLRGLHNLC AYCTHILSLY FPWDGAEVPP QRQTPAGPET EEEPYRRRNQ 430 440 450 460 ILSVLAGLAA MVGYALLSGI VSIQRATPAR APGTRTLGMA EEDEEE

CATM prediction

The sequence of MTX1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    420       430       440  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RNQILSVLAGLAAMVGYALLSGIVSIQ 7.1 -51.0° 3.3 48.0 -23.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 424, VAL, HA A, 423, SER, O 3.04Å
B, 427, GLY, HA1 A, 424, VAL, O 3.11Å
A, 424, VAL, HA B, 423, SER, O 3.04Å
A, 427, GLY, HA1 B, 424, VAL, O 3.11Å