Interleukin-18 receptor 1

UniProt data

UniProt name: IL18R_HUMAN (Q13478)

Gene name: IL18R1; Synonyms=IL1RRP

Organism: Homo sapiens (Human).

Function: Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:8626725, ECO:0000305}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 330-350, 21 AA, Helical. {ECO:0000255}.

Sequence: 541 AA

10 20 30 40 50 60 MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE TTTKSWYKSS 70 80 90 100 110 120 GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM KNYTQKWKLN VIRRNKHSCF 130 140 150 160 170 180 TERQVTSKIV EVKKFFQITC ENSYYQTLVN STSLYKNCKK LLLENNKNPT IKKNAEFEDQ 190 200 210 220 230 240 GYYSCVHFLH HNGKLFNITK TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL 250 260 270 280 290 300 LNEEDVIYWM FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV 310 320 330 340 350 360 ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI YRVDLVLFYR 370 380 390 400 410 420 HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL PRVLEKHFGY KLCIFERDVV 430 440 450 460 470 480 PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN EVRYELESGL HEALVERKIK IILIEFTPVT 490 500 510 520 530 540 DFTFLPQSLK LLKSHRVLKW KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S

CATM prediction

The sequence of IL18R_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     330       340       350 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 FTRGMIIAVLILVAVVCLVTVCVIYRV 7.1 -55.0° 5.8 47.0 -0.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 331, MET, HA A, 330, GLY, O 3.10Å
A, 331, MET, HA B, 330, GLY, O 3.10Å