UniProt data
UniProt name: PTPRS_HUMAN (Q13332)
Gene name: PTPRS
Organism: Homo sapiens (Human).
Function: Interacts with LAR-interacting protein LIP.1.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 1283-1303, 21 AA, Helical. {ECO:0000255}.
Sequence: 1948 AA
10 20 30 40 50 60
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP
70 80 90 100 110 120
KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA
130 140 150 160 170 180
KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS
190 200 210 220 230 240
NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV
250 260 270 280 290 300
RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL
310 320 330 340 350 360
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV
370 380 390 400 410 420
SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR
430 440 450 460 470 480
TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV
490 500 510 520 530 540
DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS
550 560 570 580 590 600
ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ
610 620 630 640 650 660
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP
670 680 690 700 710 720
LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP
730 740 750 760 770 780
SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA
790 800 810 820 830 840
DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV
850 860 870 880 890 900
QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT
910 920 930 940 950 960
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG
970 980 990 1000 1010 1020
AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP
1030 1040 1050 1060 1070 1080
FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR
1090 1100 1110 1120 1130 1140
TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV
1150 1160 1170 1180 1190 1200
YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR
1210 1220 1230 1240 1250 1260
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS
1270 1280 1290 1300 1310 1320
PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR
1330 1340 1350 1360 1370 1380
TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE
1390 1400 1410 1420 1430 1440
HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG
1450 1460 1470 1480 1490 1500
IMGSDYINAN YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK
1510 1520 1530 1540 1550 1560
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV
1570 1580 1590 1600 1610 1620
PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH
1630 1640 1650 1660 1670 1680
VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM
1690 1700 1710 1720 1730 1740
ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF
1750 1760 1770 1780 1790 1800
IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA
1810 1820 1830 1840 1850 1860
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI
1870 1880 1890 1900 1910 1920
GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP
1930 1940
AMVQTEDEYQ FCYQAALEYL GSFDHYAT
CATM prediction
The sequence of PTPRS_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1280 1290 1300 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | EEGLIWVIGAVLAVVFIICIVIAILLY | 7.3 | -48.1° | 0.4 | 47.0 | -14.5 |
| Prolines* | EEGLIWVIGPVLAVVFIICIVIAILLY |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1288, GLY, HA1 | A, 1285, TRP, O | 3.39Å |
| B, 1289, ALA, HA | A, 1288, GLY, O | 3.33Å |
| A, 1288, GLY, HA1 | B, 1285, TRP, O | 3.39Å |
| A, 1289, ALA, HA | B, 1288, GLY, O | 3.33Å |