Bcl-2-interacting killer

UniProt data

UniProt name: BIK_HUMAN (Q13323)

Gene name: BIK; Synonyms=NBK

Organism: Homo sapiens (Human).

Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.

Subcellular location: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Around the nuclear envelope, and in cytoplasmic membranes.

Transmembrane domains:

  1. 136-156, 21 AA, Helical. {ECO:0000255}.

Sequence: 160 AA

10 20 30 40 50 60 MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC MEGSDALALR 70 80 90 100 110 120 LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI RDVLRSFMDG FTTLKENIMR 130 140 150 FWRSPNPGSW VSCEQVLLAL LLLLALLLPL LSGGLHLLLK

CATM prediction

The sequence of BIK_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         140       150       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 CEQVLLALLLLLALLLALLSGGLHLLL 7.4 -54.2° 3.6 49.1 -4.2
Prolines* CEQVLLALLLLLALLLPLLSGGLHLLL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 150, LEU, HA A, 149, ALA, O 3.25Å
B, 153, GLY, HA1 A, 150, LEU, O 3.40Å
A, 150, LEU, HA B, 149, ALA, O 3.25Å
A, 153, GLY, HA1 B, 150, LEU, O 3.40Å