Inactive tyrosine-protein kinase 7

UniProt data

UniProt name: PTK7_HUMAN (Q13308)

Gene name: PTK7; Synonyms=CCK4

Organism: Homo sapiens (Human).

Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}.

Subcellular location: Membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269|PubMed:20837484}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Transmembrane domains:

  1. 705-725, 21 AA, Helical. {ECO:0000255}.

Sequence: 1070 AA

10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 430 440 450 460 470 480 SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 490 500 510 520 530 540 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 550 560 570 580 590 600 GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 610 620 630 640 650 660 TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 670 680 690 700 710 720 RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 730 740 750 760 770 780 GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 790 800 810 820 830 840 KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ 850 860 870 880 890 900 LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ 910 920 930 940 950 960 PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 970 980 990 1000 1010 1020 YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ 1030 1040 1050 1060 AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP

CATM prediction

The sequence of PTK7_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          710       720      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 IQTIGLSVGAAVAYIIAVLGLMFYCKK 7.2 -36.8° -0.0 36.9 -30.7
Model 2 IQTIGLSVGAAVAYIIAVLGLMFYCKK 7.4 -20.0° 2.1 45.0 -29.9
Model 3 IQTIGLSVGAAVAYIIAVLGLMFYCKK 6.6 -48.6° 1.8 44.8 -23.7
Model 4 IQTIGLSVGAAVAYIIAVLGLMFYCKK 7.4 -33.0° 2.2 35.0 -10.3
Model 5 IQTIGLSVGAAVAYIIAVLGLMFYCKK 7.2 -48.0° 1.0 37.1 -5.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 711, ALA, HA A, 710, GLY, O 3.23Å
B, 714, ALA, HA A, 715, TYR, OH 2.84Å
A, 711, ALA, HA B, 710, GLY, O 3.23Å
A, 714, ALA, HA B, 715, TYR, OH 2.84Å